Regulation of ketone body metabolism and the role of PPARα
M Grabacka, M Pierzchalska, M Dean… - International journal of …, 2016 - mdpi.com
Ketogenesis and ketolysis are central metabolic processes activated during the response to
fasting. Ketogenesis is regulated in multiple stages, and a nuclear receptor peroxisome …
fasting. Ketogenesis is regulated in multiple stages, and a nuclear receptor peroxisome …
The biochemistry of ketogenesis and its role in weight management, neurological disease and oxidative stress
PAC McPherson, J McEneny - Journal of physiology and biochemistry, 2012 - Springer
Ketogenesis is the branch of mammalian metabolism concerned with the synthesis of ketone
bodies. In this process, the small, water-soluble compounds acetoacetate, D-3-β …
bodies. In this process, the small, water-soluble compounds acetoacetate, D-3-β …
Multi-dimensional roles of ketone bodies in cancer biology: Opportunities for cancer therapy
S Feng, H Wang, J Liu, AA Jiye, F Zhou… - Pharmacological …, 2019 - Elsevier
Ketone bodies are traditionally viewed as metabolic substrates in carbohydrate restriction
and are applied in the treatment of epilepsy and other neurodegenerative diseases …
and are applied in the treatment of epilepsy and other neurodegenerative diseases …
The ketogenic diet; fatty acids, fatty acid-activated receptors and neurological disorders
TE Cullingford - Prostaglandins, Leukotrienes and Essential Fatty Acids, 2004 - Elsevier
This review outlines the molecular sensors that reprogram cellular metabolism in response
to the ketogenic diet (KD). Special emphasis is placed on the fasting-, fatty acid-and drug …
to the ketogenic diet (KD). Special emphasis is placed on the fasting-, fatty acid-and drug …
Molecular mechanisms for ketone body metabolism, signaling functions, and therapeutic potential in cancer
CY Hwang, W Choe, KS Yoon, J Ha, SS Kim, EJ Yeo… - Nutrients, 2022 - mdpi.com
The ketone bodies (KBs) β-hydroxybutyrate and acetoacetate are important alternative
energy sources for glucose during nutrient deprivation. KBs synthesized by hepatic …
energy sources for glucose during nutrient deprivation. KBs synthesized by hepatic …
Ketone bodies in the brain beyond fuel metabolism: from excitability to gene expression and cell signaling
D García-Rodríguez… - Frontiers in Molecular …, 2021 - frontiersin.org
Ketone bodies are metabolites that replace glucose as the main fuel of the brain in situations
of glucose scarcity, including prolonged fasting, extenuating exercise, or pathological …
of glucose scarcity, including prolonged fasting, extenuating exercise, or pathological …
Mitochondria: The ketogenic diet—A metabolism-based therapy
S Vidali, S Aminzadeh, B Lambert, T Rutherford… - The international journal …, 2015 - Elsevier
Mitochondria are the energy-producing organelles of the cell, generating ATP via oxidative
phosphorylation mainly by using pyruvate derived from glycolytic processing of glucose …
phosphorylation mainly by using pyruvate derived from glycolytic processing of glucose …
Modulation of cellular biochemistry, epigenetics and metabolomics by ketone bodies. Implications of the ketogenic diet in the physiology of the organism and …
A Dąbek, M Wojtala, L Pirola, A Balcerczyk - Nutrients, 2020 - mdpi.com
Ketone bodies (KBs), comprising β-hydroxybutyrate, acetoacetate and acetone, are a set of
fuel molecules serving as an alternative energy source to glucose. KBs are mainly produced …
fuel molecules serving as an alternative energy source to glucose. KBs are mainly produced …
Effects of ketone bodies on brain metabolism and function in neurodegenerative diseases
NJ Jensen, HZ Wodschow, M Nilsson… - International journal of …, 2020 - mdpi.com
Under normal physiological conditions the brain primarily utilizes glucose for ATP
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …
The evolution of ketosis: potential impact on clinical conditions
Ketone bodies are small compounds derived from fatty acids that behave as an alternative
mitochondrial energy source when insulin levels are low, such as during fasting or …
mitochondrial energy source when insulin levels are low, such as during fasting or …