Abstract The popularity of Direct Oral AntiCoagulants (DOACs) for approved indications has
risen dramatically following their introduction to the UK's National Health Service (NHS) due …

This article aims to highlight the dosing issues of direct oral anticoagulants (DOACs) in
patients with renal impairment and/or obesity in an attempt to develop solutions employing …

Abstract Purpose of Review The purpose of this review is to examine the safety and
effectiveness of direct oral anticoagulants and provide recommendations for the treatment of …

Direct oral anticoagulants (DOACs) are increasingly used for treatment and prevention of
thromboembolic diseases, used in fixed dose regimens. Although their safety and efficacy …

Atrial fibrillation (AF) has emerged as the next epi-demic in cardiovascular medicine, with
stroke being the most concerning consequence. 1 Direct oral anticoagulants (DOACs) have …

Background and purpose Renal excretion of direct oral anticoagulants (DOACs) varies
depending on the drug. Hypothetically, an increased glomerular filtration rate (GFR) may …

Patients with renal impairment require dose adjustments for direct oral anticoagulants
(DOACs), though there is uncertainty regarding their use in severe chronic kidney disease …

We read with great interest the consensus paper on the use of direct oral anticoagulants
(DOACs) in patients with chronic kidney disease (CKD) by Grandone et al.[1], underlining …

Direct oral anticoagulants (DOACs) are increasingly used for treatment and prevention of
thromboembolic diseases, used in fixed dose regimens. Although their safety and efficacy …

Essentials• The association of body weight and patient‐important outcomes remains
unknown.• Phase III randomized controlled trials of direct oral anticoagulants (DOACs) were …