Vascular smooth muscle cells (VSMCs) play an important role in the pathogenesis of
vascular remolding, such as atherosclerosis and restenosis. Solute carrier family 6 member …

In varicose veins, abnormal phenotypic transition and inflammatory response is commonly
found in venous smooth muscle cells (VSMCs). We aimed to explore the potential role and …

Introduction. Abnormal proliferation of vascular smooth muscle cells (VSMCs) can cause
various vascular diseases, such as atherosclerosis, restenosis, and pulmonary …

Background: We demonstrated that the transduction of Wnt11 into mesenchymal stem cells
(MSCs)(MSCWnt11) promotes these cells differentiation into cardiac phenotypes. In the …

Background Vascular remodelling is an essential pathophysiological state in many
circulatory diseases. Abnormal vascular smooth muscle cell (VSMC) behaviour leads to …

Emerging evidence indicates that long non-coding RNAs (lncRNAs) serve as a critical
molecular regulator in various cardiovascular diseases. Here, we aimed to identify and …

Aortic aneurysm is a life-threatening disease with limited interventions that is closely related
to vascular smooth muscle cell (VSMC) phenotypic switching. SLC44A2, a member of the …

Mutations in Wnt-signaling coreceptor LRP6 have been linked to coronary artery disease
(CAD) by unknown mechanisms. Here, we show that reduced LRP6 activity in LRP6 R611C …

Introduction: Endovascular interventions are the first line treatment for patients with
atherosclerotic disease. However, a significant number of these fail due to neointimal …

Loss of function mutations in the Wnt co-receptor Low Density Lipoprotein Receptor Related
Protein 6 (LRP6) cause early coronary artery disease (CAD) in humans. Using in vivo model …