Folate-mediated and pH-responsive chidamide-bound micelles encapsulating photosensitizers for tumor-targeting photodynamic therapy

Z Ma, P Hu, C Guo, D Wang, X Zhang… - International Journal …, 2019 - Taylor & Francis
Background: Nonspecific tumor targeting, potential relapse and metastasis of tumor after
treatment are the main barriers in clinical photodynamic therapy (PDT) for cancer, hence …

Cancer cell-specific photoactivity of pheophorbide a–glycol chitosan nanoparticles for photodynamic therapy in tumor-bearing mice

I Oh, HS Min, L Li, TH Tran, Y Lee, IC Kwon, K Choi… - Biomaterials, 2013 - Elsevier
We designed a cancer-cell specific photosensitizer nano-carrier by synthesizing
pheophorbide a (PheoA) conjugated glycol chitosan (GC) with reducible disulfide bonds …

Pheophorbide a-conjugated ph-sensitive nanoparticle vectors for highly efficient photodynamic therapy of cancer

L Zhao, TH Kim, HW Kim, SY Kim - International Journal of …, 2015 - Taylor & Francis
To achieve a tumor-targeted drug delivery system for photodynamic therapy, we designed
ligand-mediated nanoparticles with stable formulations of a hydrophobic photosensitizer …

Tumor-homing photosensitizer-conjugated glycol chitosan nanoparticles for synchronous photodynamic imaging and therapy based on cellular on/off system

SJ Lee, H Koo, DE Lee, S Min, S Lee, X Chen, Y Choi… - Biomaterials, 2011 - Elsevier
Herein, we developed the photosensitizer, protoporphyrin IX (PpIX), conjugated glycol
chitosan (GC) nanoparticles (PpIX–GC–NPs) as tumor-homing drug carriers with cellular …

Tumor-targeting photodynamic therapy based on folate-modified polydopamine nanoparticles

S Yan, Q Huang, J Chen, X Song, Z Chen… - International Journal …, 2019 - Taylor & Francis
Background Photodynamic therapy (PDT), a clinical anticancer therapeutic modality, has a
long history in clinical cancer treatments since the 1970s. However, PDT has not been …

Fluorene–morpholine-based organic nanoparticles: lysosome-targeted pH-triggered two-photon photodynamic therapy with fluorescence switch on–off

M Gangopadhyay, SK Mukhopadhyay… - Journal of materials …, 2016 - pubs.rsc.org
Nanocarrier-mediated photodynamic therapy (PDT) is an effective tool for anti-tumour
treatment due to the targeted and image-guided delivery of photosensitizers (PSs) to …

Self-assembled photosensitizer-conjugated nanoparticles for targeted photodynamic therapy

L Zhao, TH Kim, KM Huh, HW Kim… - Journal of Biomaterials …, 2013 - journals.sagepub.com
An effective tumor-targeted drug delivery system for photodynamic therapy was developed
by designing ligand-mediated nanoparticles with stable formulations of a hydrophobic …

PEGylated dimeric BODIPY photosensitizers as nanocarriers for combined chemotherapy and cathepsin B-activated photodynamic therapy in 3D tumor spheroids

S Lu, X Lei, H Ren, S Zheng, J Qiang… - ACS Applied Bio …, 2020 - ACS Publications
The development of enzyme-activatable photosensitizers and their combination with
conventional chemodrugs for antitumor therapy are of great interest. In this work, we …

Targeted and oxygen-enriched polymeric micelles for enhancing photodynamic therapy

TH Tseng, CY Chen, WC Wu, CY Chen - Nanotechnology, 2021 - iopscience.iop.org
Photodynamic therapy (PDT) has been emerged as an alternative therapeutic modality in
treatment of several malignant tumors. However, the therapeutic efficacy of PDT is often …

Hypocrellin B‐loaded, folate‐conjugated polymeric micelle for intraperitoneal targeting of ovarian cancer in vitro and in vivo

J Li, S Yao, K Wang, Z Lu, X Su, L Li, C Yuan… - Cancer …, 2018 - Wiley Online Library
Photodynamic therapy (PDT) is considered an innovative and attractive modality to treat
ovarian cancer. In the present study, a biodegradable polymer poly (ethylene glycol)(PEG) …