Two are the issues on cannabis addiction that provoke more controversy from a research
perspective. The first one is related to the development of tolerance phenomena and, in …

Different animal models have been used to clarify the consequences of chronic exposure to
cannabinoid agonists and their abuse liability. Following the chronic administration of …

Recent studies have demonstrated that the pharmacological tolerance observed after
prolonged exposure to plant or synthetic cannabinoids in adult individuals seems to have a …

The active ingredient of marijuana is (−)-Δ 9-tetrahydrocannabinol (Δ 9-THC). Δ 9-THC and
other natural and synthetic cannabinoids such as CP-55, 940 inhibit spontaneous activity …

Whether chronic cannabinoid consumption produces a dependent state comparable to that
occurring with other drugs (eg the appearance of withdrawal signs when consumption is …

This study compared the potency and efficacy of the cannabinoids Δ 9-tetrahydrocannabinol
(Δ 9-THC), HU-210, WIN 55, 212-2 and CP 55, 940 in suppressing food-reinforced operant …

Previous data showed the development of tolerance to a variety of pharmacological effects
of plant and synthetic cannabinoids when administered chronically. This tolerance …

To characterize the time course of the behavioral and biochemical aspects of the
cannabinoid withdrawal syndrome, we injected the cannabinoid antagonist SR141716A (5 …

Considerable plasticity exists in the endogenous cannabinoid system, as evidenced by the
high degree of tolerance that develops following repetitive exposure to exogenously …

Marijuana produces a number of characteristic behaviors in humans and animals, including
memory impairment, antinociception, and locomotor and psychoactive effects. However …