Efficient in silico development of novel antibiotics requires high-resolution, dynamic models
of drug targets. As conjugation is considered the prominent contributor to the spread of …

Antimicrobial resistance is a mounting global health crisis that threatens a resurgence of life-
threatening bacterial infections. Despite intensive drug discovery efforts, the rate of …

Type IV secretion systems (T4SSs) are nanomachines that Gram-negative, Gram-positive
bacteria, and some archaea use to transport macromolecules across their membranes into …

Conjugative DNA transfer is the most important means to transfer antibiotic resistance genes
and virulence determinants encoded by plasmids, integrative conjugative elements (ICE) …

Conjugation is one of the most important processes that bacteria utilize to spread antibiotic
resistance genes among bacterial populations. Interbacterial DNA transfer requires a large …

Bacterial conjugation is one of the main mechanisms for horizontal gene transfer. It
constitutes a key element in the dissemination of antibiotic resistance and virulence genes to …

Bacterial type IV secretion systems (T4SSs) are a functionally diverse translocation
superfamily. They consist mainly of two large subfamilies:(i) conjugation systems that …

Bacterial type IV secretion systems (T4SSs) are a versatile group of nanomachines that can
horizontally transfer DNA through conjugation and deliver effector proteins into a wide range …

Bacterial conjugation systems are members of the large type IV secretion system (T4SS)
superfamily. Conjugative transfer of F plasmids residing in the Enterobacteriaceae was first …

The bacterial type IV secretion systems (T4SSs) comprise a biologically diverse group of
translocation systems functioning to deliver DNA or protein substrates from donor to target …