Most metastatic cancers remain incurable due to the emergence of apoptosis-resistant
clones, fuelled by intratumour heterogeneity and tumour evolution. To improve treatment …

Our conception of programmed cell death has expanded beyond apoptosis to encompass
additional forms of cell suicide, including necroptosis and pyroptosis; these cell death …

Necroptosis is one the best‐characterized forms of regulated necrosis. Necroptosis is
mediated by the kinase activities of receptor interacting protein kinase‐1 and receptor …

Immune-checkpoint blockers (ICBs) have revolutionized oncology and firmly established the
subfield of immuno-oncology. Despite this renaissance, a subset of cancer patients remain …

Resistance to caspase‐dependent apoptosis is often responsible for treatment failures in
cancer. Finding novel therapeutic strategies that can activate alternative cell death programs …

Induction of cell death is inexorably linked with cancer therapy, but this can also initiate
wound-healing processes that have been linked to cancer progression and therapeutic …

While the mechanisms underlying apoptosis and autophagy have been well characterized
over recent decades, another regulated cell death event, necroptosis, remains poorly …

Cancer immunotherapy has been acknowledged as a new paradigm for cancer treatment,
with notable therapeutic effects on certain cancer types. Despite their significant potential …

Necroptosis, a form of programmed necrotic cell death, is a gatekeeper of host defense
against certain pathogen invasions. The deregulation of necroptosis is also a key factor of …

Evasion of programmed cell death represents one of the hallmarks of cancers that
contributes to tumor initiation, progression and treatment resistance. This calls for novel …