The ureohydrolase, type-II arginase (Arg-II), is a mitochondrial enzyme metabolizing L-
arginine into urea and L-ornithine and is highly expressed in renal proximal tubular cells …

Hypoxia plays a crucial role in acute and chronic renal injury, which is attributable to renal
tubular and glomerular cell damage. Some studies provide evidence that hypoxia …

Novel therapeutic interventions for preventing or attenuating kidney injury following
ischemia-reperfusion injury (IRI) remain a focus of significant interest. Currently, there are no …

Abstract Aim Arginase 2 (ARG2) is a mitochondrial enzyme that catalyses hydrolysis of l‐
arginine into urea and l‐ornithine. In the kidney, ARG2 is localized to the S3 segment of the …

The aging kidney undergoes complex changes and is vulnerable to injury and development
of chronic kidney disease (CKD) with preponderance affecting more women than men …

Background Hypoxia contributes to a cascade of inflammatory response mechanisms in
kidneys that result in the development of renal interstitial fibrosis and subsequent chronic …

Abstract Hypoxia-inducible factor-1 (HIF-1) could ameliorate renal ischemia reperfusion
injury (IRI), but the underlying mechanism remains elusive. In the current study, we aim to …

Obesity is associated with development and progression of chronic kidney disease (CKD).
Recent evidence demonstrates that enhanced levels of the L-arginine: ureahydrolase …

Kidney ischemia–reperfusion injury is a major cause of acute kidney injury (AKI). Following
reduced kidney perfusion, the pathological overproduction of reactive oxygen and reactive …

Hypoxia plays a crucial role in the pathogenesis of cardiovascular diseases. Mitochondrial
enzyme arginase type II (Arg-II) is reported to lead to endothelial dysfunction and enhance …