Stem cell bioprocessing: fundamentals and principles

MR Placzek, IM Chung, HM Macedo… - Journal of the …, 2009 - royalsocietypublishing.org
In recent years, the potential of stem cell research for tissue engineering-based therapies
and regenerative medicine clinical applications has become well established. In 2006 …

[PDF][PDF] Current understanding and challenges in bioprocessing of stem cell-based therapies for regenerative medicine

E Ratcliffe, RJ Thomas, DJ Williams - British medical bulletin, 2011 - researchgate.net
Background: A novel manufacturing industry is emerging to translate unique cellular therapy
bioprocesses to robust, scaled manufacturing production for successful clinical translation …

Scale-up of human mesenchymal stem cell culture: current technologies and future challenges

QA Rafiq, K Coopman, CJ Hewitt - Current Opinion in Chemical …, 2013 - Elsevier
Regenerative medicine technologies have the potential to revolutionise human healthcare.
However, whilst science has revealed the potential, and early products have shown the …

Stem cells bioprocessing: an important milestone to move regenerative medicine research into the clinical arena

JM Polak, S Mantalaris - Pediatric research, 2008 - nature.com
Regenerative Medicine is a new, multidisciplinary field that combines expertise in biology,
chemistry, engineering, materials, and medicine, to find solutions to some of the most …

Manufacture of a human mesenchymal stem cell population using an automated cell culture platform

RJ Thomas, A Chandra, Y Liu, PC Hourd, PP Conway… - Cytotechnology, 2007 - Springer
Tissue engineering and regenerative medicine are rapidly developing fields that use cells or
cell-based constructs as therapeutic products for a wide range of clinical applications. Efforts …

Isolation and production of cells suitable for human therapy: challenges ahead

L Ährlund-Richter, M De Luca, DR Marshak, M Munsie… - Cell Stem Cell, 2009 - cell.com
Considerable practical hurdles must be overcome prior to the broad application of stem cell
therapies. We outline challenges that may vary across different models of cell therapy …

Stem cell bioengineering

PW Zandstra, A Nagy - Annual Review of Biomedical …, 2001 - annualreviews.org
▪ Abstract Tissue engineering and cellular therapies, either on their own or in combination
with therapeutic gene delivery, have the potential to significantly impact medicine …

Current status and perspectives on stem cell-based therapies undergoing clinical trials for regenerative medicine: case studies

E Ratcliffe, KE Glen, MW Naing… - British medical …, 2013 - academic.oup.com
Background Apart from haematopoietic stem cell transplantation for haematological
disorders many stem cell-based therapies are experimental. However, with only 12 years …

[图书][B] Advances in tissue engineering

JM Polak - 2008 - books.google.com
Advances in Tissue Engineering is a unique volume and the first of its kind to bring together
leading names in the field of tissue engineering and stem cell research. A relatively young …

Stem cell culture engineering–process scale up and beyond

S Sharma, R Raju, S Sui, WS Hu - Biotechnology journal, 2011 - Wiley Online Library
Advances in stem cell research and recent work on clinical trials employing stem cells have
heightened the prospect of stem cell applications in regenerative medicine. The eventual …