Deer antlers: the fastest growing tissue with least cancer occurrence

C Li, Y Li, W Wang, M Scimeca, G Melino… - Cell Death & …, 2023 - nature.com
Deer antlers are a bony organ solely able to acquired distinct unique attributes during
evolution and all these attributes are against thus far known natural rules. One of them is as …

Anti-tumour activity of deer growing antlers and its potential applications in the treatment of malignant gliomas

L Chonco, T Landete-Castillejos, G Serrano-Heras… - Scientific Reports, 2021 - nature.com
A recent study showed that antlers have evolved a high rate of growth due to the expression
of proto-oncogenes and that they have also evolved to express several tumour suppressor …

Deer antlers–a model of mammalian appendage regeneration: an extensive review

U Kierdorf, H Kierdorf - Gerontology, 2011 - karger.com
Background: Compared with other vertebrate taxa, mammals possess a very limited capacity
for appendage regeneration. The antlers of deer are an exception in that they are …

Deer antler–a novel model for studying organ regeneration in mammals

C Li, H Zhao, Z Liu, C McMahon - … journal of biochemistry & cell biology, 2014 - Elsevier
Deer antler is the only mammalian organ that can fully grow back once lost from its pedicle–
the base from which it grows. Therefore, antlers probably offer the most pertinent model for …

Deer antlers: a zoological curiosity or the key to understanding organ regeneration in mammals?

JS Price, S Allen, C Faucheux, T Althnaian… - Journal of …, 2005 - Wiley Online Library
Many organisms are able to regenerate lost or damaged body parts that are structural and
functional replicates of the original. Eventually these become fully integrated into pre …

Programmed cell death in the regenerating deer antler

M Colitti, SP Allen, JS Price - Journal of anatomy, 2005 - Wiley Online Library
Antlers are the only mammalian appendages capable of epimorphic regeneration and thus
provide a unique model for investigating the mechanisms that underlie mammalian …

Histological examination of antler regeneration in red deer (Cervus elaphus)

C Li, JM Suttie, DE Clark - … Biology: An Official Publication of the …, 2005 - Wiley Online Library
Annual antler renewal presents the only case of epimorphic regeneration (de novo formation
of a lost appendage distal to the level of amputation) in mammals. Epimorphic regeneration …

[HTML][HTML] New physiological insights into the phenomena of deer antler: A unique model for skeletal tissue regeneration

M Feleke, S Bennett, J Chen, X Hu, D Williams… - Journal of Orthopaedic …, 2021 - Elsevier
Generally, mammals are unable to regenerate complex tissues and organs however the
deer antler provides a rare anomaly to this rule. This osseous cranial appendage which is …

Cell cycle genes PEDF and CDKN1C in growing deer antlers

EA Lord, SK Martin, JP Gray, C Li… - The Anatomical Record …, 2007 - Wiley Online Library
Deer antlers are the only mammalian appendage to display an annual cycle of full
regeneration. The growth phase in antler involves the rapid proliferation of several tissues …

Deer antler stem cells are a novel type of cells that sustain full regeneration of a mammalian organ—deer antler

D Wang, D Berg, H Ba, H Sun, Z Wang, C Li - Cell Death & Disease, 2019 - nature.com
Deer antlers are extraordinary mammalian organs that can fully regenerate annually. Antler
renewal is a stem cell-based epimorphic process and antler stem (AS) cells can initiate de …