This study aimed to determine whether Bmi-1 deficiency leads to intestinal epithelial barrier
destruction and microbiota dysfunction, which members of the microbial community alter …

To determine whether p16 INK4a deletion ameliorated renal tubulointerstitial injury by
inhibiting a senescence-associated secretory phenotype (SASP) in Bmi-1-deficient (Bmi …

Abstract Background and Aims Disruption of the intestinal barrier of the digestive tract is a
common pathophysiological change in the elderly, which may partly contribute to gut …

Inflammatory bowel diseases (IBDs) are immune chronic diseases characterized by
recurrent episodes, resulting in continuous intestinal barrier damage and intestinal …

To understand the role of commensal gut bacteria on the progression of cognitive decline in
Alzheimer's disease via the microbiota-gut-brain axis, we isolated anti-inflammatory …

Age-related gut barrier dysfunction and dysbiosis of the gut microbiome play crucial roles in
human aging. Dietary methionine restriction (MR) has been reported to extend lifespan and …

Background Dysbiosis and mucin depletion are related with intestinal barrier dysfunction
and seems to be an early pathophysiological event in inflammatory bowel disease (IBD) …

Purpose The senescence-accelerated prone mouse 8 (SAMP8) is a widely used model for
accelerating aging, especially in central aging. Mounting evidence indicates that the …

The postnatal period is one of the critical windows for the structure‐function development of
the gastrointestinal tract and associated mucosal immunity. Along with other constituent …

Background & Aims Gut dysbiosis is closely involved in the pathogenesis of inflammatory
bowel disease (IBD). However, it remains unclear whether IBD-associated gut dysbiosis …