Every day, megakaryocytes produce billions of platelets that circulate for several days and
eventually are cleared by the liver. The exact removal mechanism, however, remains …

Most platelet membrane proteins are modified by mucin-type core 1-derived glycans (O-
glycans). However, the biological importance of O-glycans in platelet clearance is unclear …

In recent years, it has become increasingly apparent that the life span of transfused platelets
in circulation is regulated, at least in part, by glycan‐lectin mediated mechanisms. There is …

The liver has recently been identified as a major organ for destruction of desialylated
platelets. However, the underlying mechanism remains unclear. Kupffer cells, which are …

Macrophages play a key role in atherosclerotic plaque destabilization and rupture. In this
light, selective removal of macrophages may be beneficial for plaque stability. However …

Background Macrophages are the dominant phagocyte at sites of wound healing and
inflammation, and the cellular and acellular debris encountered by macrophages can have …

Hundreds of billions of platelets are cleared daily from circulation via efficient and highly
regulated mechanisms. These mechanisms may be stimulated by exogenous reagents or …

Autophagy is important for maintaining cellular homeostasis, and thus its deficiency is
implicated in a broad spectrum of human diseases. Its role in platelet function has only …

The human body produces and removes 1011 platelets daily to maintain a normal steady
state platelet count. Platelet production must be regulated to avoid spontaneous bleeding or …

Growing evidence supports a pathophysiological role for platelets during the manifestation
of postischemic reperfusion injury; in the current study, we investigated the nature and the …