Novel purification strategy for human PON1 and inhibition of the activity by cephalosporin and aminoglikozide derived antibiotics

S Sinan, F Kockar, O Arslan - Biochimie, 2006 - Elsevier
Human serum paraoxonase (PON1, EC 3.1. 8.1.) is a high-density lipid (HDL)-associated,
calcium-dependent enzyme; its physiological substrates are not known. In this study, a new …

Identification of paraoxonase 3 in rat liver microsomes: purification and biochemical properties

L Rodrigo, F Gil, AF Hernandez, O Lopez… - Biochemical …, 2003 - portlandpress.com
Three paraoxonase genes (PON1, PON2 and PON3) have been described so far in
mammals. Although considerable information is available regarding PON1, little is known …

[HTML][HTML] Development of an immunoblot assay with infrared fluorescence to quantify paraoxonase 1 in serum and plasma

PW Connelly, GF Maguire, CM Picardo, JF Teiber… - Journal of lipid …, 2008 - ASBMB
Paraoxonase 1 (PON1) requires calcium for activity and is inactivated in the presence of
EDTA. Because of this, studies to date have used serum or heparinized plasma for both …

In vitro inhibition effect of some dihydroxy coumarin compounds on purified human serum paraoxonase 1 (PON1)

M Erzengin, I Basaran, U Cakir, A Aybey… - Applied biochemistry and …, 2012 - Springer
Abstract Human serum paraoxonase 1 (PON1; EC 3.1. 8.1) is a high-density lipoprotein
associated, calcium-dependent enzyme that hydrolyses aromatic esters, organophosphates …

[PDF][PDF] Species-and substrate-specific stimulation of human plasma paraoxonase 1 (PON1) activity by high chloride concentration.

J Bełtowski, G Wójcicka, A Marciniak - Acta Biochimica Polonica, 2002 - bibliotekanauki.pl
Paraoxonase 1 (PON1), contained in plasma high-density lipoproteins, plays an important
role in the protection of plasma lipoproteins and cell membranes from oxidative damage …

Human serum paraoxonase (PON1): identification of essential amino acid residues by group-selective labelling and site-directed mutagenesis

D Josse, W Xie, P Masson, O Lockridge - Chemico-biological interactions, 1999 - Elsevier
Human serum paraoxonase/arylesterase (PON1, EC 3.1. 8.1.) is a calcium-dependent
enzyme which hydrolyzes a wide variety of organophosphates, including paraoxon, DFP …

Simple procedures for purification and stabilization of human serum paraoxonase-1

L Golmanesh, H Mehrani, M Tabei - Journal of biochemical and biophysical …, 2008 - Elsevier
Human paraoxonases-1 is one of the most important detoxifying enzymes. In this study
using simple chromatographic procedures human paraoxonases-1 was purified from human …

Impacts of some antibiotics on human serum paraoxonase 1 activity

EB Dilek, Öİ Küfrevioğlu, Ş Beydemir - Journal of enzyme inhibition …, 2013 - Taylor & Francis
Some enzymes are known to be drug target inhibitions of which can be critical for
organisms. PON has a critical role to prevent atherogenesis by inhibiting lipid peroxidation. It …

3-D structure of serum paraoxonase 1 sheds light on its activity, stability, solubility and crystallizability

M Harel, B Brumshtein, R Meged, H Dvir… - Arhiv za higijenu rada i …, 2007 - hrcak.srce.hr
Sažetak Serum paraoxonases (PONs) exhibit a wide range of physiologically important
hydrolytic activities, including drug metabolism and detoxification of nerve gases. PON1 and …

The inhibition effects of some sulfonamides on human serum paraoxonase-1 (hPON1)

Y Demir, Z Köksal - Pharmacological reports, 2019 - Springer
Abstract Background Paraoxonase 1 (PON1) is an antiatherogenic and organophosphate
hydrolyzer enzyme. It has important roles including protecting low density lipoprotein (LDL) …