Molecules involved in regulation of osteoblast activity and osteoclast activity, and methods of use thereof
LH Glimcher, DC Jones, AO Aliprantis - US Patent 8,357,637, 2013 - Google Patents
The present invention is based, at least in part, on the identi fication of molecules involved in
the differentiation and/or activity of osteoblasts and osteoclasts. Accordingly, the present …
the differentiation and/or activity of osteoblasts and osteoclasts. Accordingly, the present …
Molecules involved in regulation of osteoblast activity and osteoclast activity, and methods of use thereof
LH Glimcher, DC Jones, AO Aliprantis - US Patent App. 12/598,495, 2010 - Google Patents
The present invention is based, at least in part, on the identi fication of molecules involved in
the differentiation and/or activity of osteoblasts and osteoclasts. Accordingly, the present …
the differentiation and/or activity of osteoblasts and osteoclasts. Accordingly, the present …
Methods for identification of bone anabolic agents
C Basilico, A Mansukhani, UB Roy - US Patent 8,404,442, 2013 - Google Patents
The present invention is related to methods for identifying bone anabolic agents and factors,
identifying pathways that promote proliferation of osteoblasts for bone growth and/or repair …
identifying pathways that promote proliferation of osteoblasts for bone growth and/or repair …
Methods and compositions to promote bone homeostasis
L Van Rompaey, P Tomme - US Patent App. 11/166,412, 2006 - Google Patents
Methods are disclosed for identifying osteogenic promoting compounds by contacting test
compounds with a target gene polypeptide or fragment thereof, which target gene is iden …
compounds with a target gene polypeptide or fragment thereof, which target gene is iden …
Gene expression associated with osteoblast differentiation
MS Spring, N Zamurovic - US Patent App. 11/924,367, 2008 - Google Patents
The present invention identifies genes whose expression pat tern is altered when pre-
osteoblastic cells undergo differen tiation into mature osteoblasts. The genes identified may …
osteoblastic cells undergo differen tiation into mature osteoblasts. The genes identified may …
Controlling osteogenesis by inhibition of osteogenic suppressors
Y Zhao, S Ding - US Patent App. 12/376,645, 2010 - Google Patents
The present invention provides methods of screening for agents that inhibit the activity or
expression of one or more polypeptides that contribute to the Suppression of osteogen esis …
expression of one or more polypeptides that contribute to the Suppression of osteogen esis …
Controlling osteogenesis by inhibition of osteogenic suppressors
Y Zhao, S Ding - US Patent 7,601,501, 2009 - Google Patents
The present invention provides methods of screening for agents that inhibit the activity or
expression of one or more polypeptides that contribute to the Suppression of osteogen esis …
expression of one or more polypeptides that contribute to the Suppression of osteogen esis …
Methods for inducing differentiation of undifferentiated mammalian cells into osteoblasts
LJC Van Rompaey, PHM Tomme, RJ Brown - US Patent 8,338,124, 2012 - Google Patents
The present invention relates to in vivo and in vitro methods, agents and compound
screening assays for inducing differ entiation of undifferentiated mammalian cells into osteo …
screening assays for inducing differ entiation of undifferentiated mammalian cells into osteo …
Gene expression associated with osteobla st differentiation
MS Spring, N Zamurovic - US Patent App. 10/552,319, 2007 - Google Patents
0001. The present invention identifies genes, eg Hey 1, whose expression pattern is altered
when precursor pre osteoblastic cells undergo differentiation into osteoblasts. The genes …
when precursor pre osteoblastic cells undergo differentiation into osteoblasts. The genes …
Methods for inducing differentiation of undifferentiated mammalian cells into osteoblasts
LJC Van Rompaey, PHM Tomme, RJ Brown - US Patent 7,638,288, 2009 - Google Patents
The present invention relates to in vivo and in vitro methods, agents and compound
screening assays for inducing differ entiation of undifferentiated mammalian cells into osteo …
screening assays for inducing differ entiation of undifferentiated mammalian cells into osteo …