Approaches to triage optimization in HPV primary screening: extended genotyping and p16/Ki‐67 dual‐stained cytology—retrospective insights from ATHENA

MH Stoler, E Baker, S Boyle, S Aslam… - … Journal of Cancer, 2020 - Wiley Online Library
The objective of our study was to assess the performance of different triage strategies for
high‐risk human papillomavirus (hrHPV)‐positive results utilizing either extended …

Triaging HPV-positive women with p16/Ki-67 dual-stained cytology: results from a sub-study nested into the ATHENA trial

TC Wright Jr, CM Behrens, J Ranger-Moore… - Gynecologic …, 2017 - Elsevier
Objectives In addition to genotyping for HPV16/18, dual-immunostaining for p16/Ki-67 has
shown promise as a triage of HPV-positive women. We assessed the performance of p16/Ki …

Comparing triage algorithms using HPV DNA genotyping, HPV E7 mRNA detection and cytology in high-risk HPV DNA-positive women

R Luttmer, J Berkhof, MG Dijkstra… - Journal of Clinical …, 2015 - Elsevier
Background High-risk human papillomavirus (hrHPV) DNA positive women require triage
testing to identify those with high-grade cervical intraepithelial neoplasia or cancer (≥ …

Clinical validation of p16/Ki‐67 dual‐stained cytology triage of HPV‐positive women: results from the IMPACT trial

TC Wright Jr, MH Stoler… - … journal of cancer, 2022 - Wiley Online Library
Triage strategies are needed for primary human papillomavirus (HPV)‐based cervical
cancer screening to identify women requiring colposcopy/biopsy. We assessed the …

Defining optimal triage strategies for hrHPV screen–positive women—an evaluation of HPV 16/18 genotyping, cytology, and p16/Ki-67 cytoimmunochemistry

GA Stanczuk, GJ Baxter, H Currie, W Forson… - … Biomarkers & Prevention, 2017 - AACR
Background: Several options for the triage of high-risk HPV screen–positive (hrHPV+)
women were assessed. Methods: This study incorporated CIN2+ cases and controls, all of …

How to triage HPV positive cases: Results of four million females

M Gultekin, S Dundar, B Keskinkilic, M Turkyilmaz… - Gynecologic …, 2020 - Elsevier
Abstract Objective To evaluate the Turkey's nationwide HPV DNA screening program on the
basis of first 4 million screened women. Methods Women over age 30 were invited for …

Triage strategies for non-16/non-18 HPV-positive women in primary HPV-based cervical cancer screening: p16/Ki67 dual stain vs. cytology

K Mazurec, M Trzeszcz, M Mazurec, J Streb, A Halon… - Cancers, 2023 - mdpi.com
Simple Summary Cervical cancer is often caused by certain high-risk types of human
papillomavirus (HPV), mainly types 16 and 18. However, there are 12 other high-risk HPV …

[HTML][HTML] Evaluation of p16/Ki-67 dual-stained cytology as triage test for high-risk human papillomavirus-positive women

RMF Ebisch, J Van Der Horst, M Hermsen… - Modern Pathology, 2017 - Elsevier
The aim of this study was to evaluate the clinical utility of p16/Ki-67 dual staining, for the
identification of CIN in high-risk HPV-positive women from a non-responder screening …

The clinical value of HPV genotyping in triage of women with high‐risk‐HPV‐positive self‐samples

RMF Ebisch, GM de Kuyper–de Ridder… - … journal of cancer, 2016 - Wiley Online Library
Cytology alone, or combined with HPV16/18 genotyping, might be an acceptable method for
triage in hrHPV‐cervical cancer screening. Previously studied HPV‐genotype based triage …

Management of high-risk HPV-positive women for detection of cervical (pre) cancer

R Luttmer, LMA De Strooper… - Expert review of …, 2016 - Taylor & Francis
Introduction: Primary HPV-testing has been shown to provide a superior detection of women
at risk of cervical (pre) cancer compared to cytology-based screening. However, as most …