Abstract Context: Congenic NOD. ABH D18Mit8-D18Mit214 mice, which contain greater
than 12.8 Mb of DNA encompassing Idd21. 1 from diabetes-resistant Biozzi/ABH mice, have …

Comparative mapping between the human and rodent genomes is one approach for
positional cloning of complex disease loci. The human type 1 diabetes susceptibility locus …

Several genetic insulin-dependent diabetes (Idd) intervals that confer resistance to
autoimmune diabetes have been identified in mice and humans, but the mechanisms by …

Type 1 diabetes results from autoimmune‐mediated pancreatic beta‐cell destruction and
transforming growth factor‐beta (TGF‐β) is known to play a preventive role in type 1 …

Twenty-four named Idd loci that contribute to the development of autoimmune diabetes in
the nonobese diabetic (NOD) mouse have been mapped by linkage and congenic analysis …

Abstract NOD. Idd3/5 congenic mice have insulin-dependent diabetes (Idd) regions on
chromosomes 1 (Idd5) and 3 (Idd3) derived from the nondiabetic strains B10 and B6 …

BACKGROUND: Transgenic mice over-expressing SMAD7 in pancreatic beta-cells develop
type 2 diabetes (T2D). The expression of SMAD7 is affected by KLF11, which contains gene …

The Idd5 locus for autoimmune diabetes in nonobese diabetic (NOD) mice has been
mapped to the proximal half of chromosome 1 and appears to include two loci, Idd5. 1 and …

Understanding signaling pathways that regulate pancreatic β-cell function to produce, store,
and release insulin, as well as pathways that control β-cell proliferation, is vital to find new …

Abstract Type 1 diabetes (T1D) results from complex interactions between genetic and
environmental factors. The nonobese diabetic (NOD) mouse develops spontaneous T1D …