Background The impact of gender-affirming testosterone on fertility is poorly understood,
with ovarian histopathologic studies showing variable results, some with a detrimental effect …

Transgender and nonbinary people with female birth sex may utilize testosterone therapy for
masculinization. Individuals interested in reproduction using their own gametes should be …

Some transmasculine individuals may be interested in pausing gender-affirming
testosterone therapy and carrying a pregnancy. The ovarian impact of taking and pausing …

STUDY QUESTION Does testosterone use in females affect reproductive potential,
particularly with regard to the production of fertilizable gametes? SUMMARY ANSWER …

Abstract Purpose of Review Hormonal and surgical treatments for transgender individuals
can severely impact reproductive potential. In this review, we discuss the role of fertility …

STUDY QUESTION Can mice serve as a translational model to investigate the reproductive
effects of testosterone (T) therapy commonly used by transgender men? SUMMARY …

Androgens are essential in normal ovarian function and follicle health, but
hyperandrogenism, as seen in polycystic ovary syndrome, is associated with disordered …

Studies show that a subset of transgender men desire children; however, there is a paucity
of literature on the effect of gender-affirming testosterone therapy on reproductive function. In …

Purpose This study compared the therapeutic effects of transdermal testosterone gel (TTG)
application at 4 and 6 weeks before controlled ovarian hyperstimulation (COH) in women …

Testosterone, an androgen that directly binds to the androgen receptor, has been shown in
previous small randomized controlled trials to increase the reproductive outcomes of poor …