Post-translational modifications and subcellular localizations modulate transcription factors,
generating a code that is deciphered into an activity. We describe our current understanding …

Publisher Summary The discovery of ets proteins as transcription factors provided a
framework for understanding the oncogenic potential of ets genes. Ets proteins became a …

Members of the Ets family of transcriptional regulators play pivotal roles in physiological
processes, such as embryonic development or immune response. The Ets family proteins …

Ets factors are members of one of the largest families of evolutionarily conserved
transcription factors, regulating critical functions in normal cell homeostasis, which when …

Cancer can be defined as a genetic disease, resulting as a consequence of multiple events
associated with initiation, promotion and metastatic growth. Cancer results from the loss of …

The Ets family consists of a large number of evolutionarily conserved transcription factors,
many of which have been implicated in tumor progression. Extensive studies on this family …

Transcription factors provide nodes of information integration by serving as nuclear effectors
of multiple signaling cascades, and thus elaborate layers of regulation, often involving post …

ETS proteins form one of the largest families of signal-dependent transcriptional regulators,
mediating cellular proliferation, differentiation and tumorigenesis. Most of the known ETS …

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The c-ets1 gene product (Ets1) is the prototype of a family of sequence-specific
transcriptional activators which have been implicated in various developmental processes …