Computational modeling has emerged as a critical tool in investigating the complex
molecular processes involved in biological systems and diseases. In this study, we apply …

Quantitative systems pharmacology (QSP) is an emerging discipline that aims to discover
how drugs modulate the dynamics of biological components in molecular and cellular …

Motivation Literature on complex diseases is abundant but not always quantitative. Many
molecular pathways are qualitatively well described but this information cannot be used in …

Parkinson's disease (PD) is a complex neurodegenerative disorder. The identification of
genetic variants has shed light on the molecular pathways for inherited PD, while the …

Parkinson's disease (PD) is a prime example of a complex and heterogeneous disorder,
characterized by multifaceted and varied motor-and non-motor symptoms and different …

Parkinson's disease (PD) is a major neurodegenerative chronic disease, most likely caused
by a complex interplay of genetic and environmental factors. Information on various aspects …

The development of novel high-throughput technologies has opened up the opportunity to
deeply characterize patient tissues at various molecular levels and has given rise to a …

Mathematical modeling of biological processes provides deep insights into complex cellular
systems. While quantitative and continuous models such as differential equations have been …

The most common treatment strategies for Parkinson's disease (PD) aim to slow down the
neurodegeneration process or control the symptoms. In this study, using an in vitro PD …

The biomolecules inside or near cells form a complex interacting system. Cellular
phenotypes and behaviors arise from the totality of interactions among the components of …