Scratching the surface of the protein corona: Challenging measurements and controversies

PL Latreille, M Le Goas, S Salimi, J Robert… - ACS …, 2022 - ACS Publications
This Review aims to provide a systematic analysis of the literature regarding ongoing
debates in protein corona research. Our goal is to portray the current understanding of two …

Protein corona formation around nanoparticles–from the past to the future

P Del Pino, B Pelaz, Q Zhang, P Maffre… - Materials …, 2014 - pubs.rsc.org
The protein adsorption layer (aka the “protein corona”) that forms on the surface of colloidal
nanoparticles plays an important role in their interaction with living matter. Thus …

Mechanistic understanding of protein Corona formation around nanoparticles: old puzzles and new insights

K Nienhaus, GU Nienhaus - Small, 2023 - Wiley Online Library
Although a wide variety of nanoparticles (NPs) have been engineered for use as disease
markers or drug delivery agents, the number of nanomedicines in clinical use has hitherto …

[HTML][HTML] Protein corona–from molecular adsorption to physiological complexity

L Treuel, D Docter, M Maskos… - Beilstein journal of …, 2015 - beilstein-journals.org
In biological environments, nanoparticles are enshrouded by a layer of biomolecules,
predominantly proteins, mediating its subsequent interactions with cells. Detecting this …

A decade of the protein corona

PC Ke, S Lin, WJ Parak, TP Davis, F Caruso - ACS nano, 2017 - ACS Publications
In this Perspective, we reflect on a decade of research on the protein corona and
contemplate its broad implications for future science and engineering at the bio–nano …

Possibilities and limitations of different separation techniques for the analysis of the protein corona

C Weber, S Morsbach… - Angewandte Chemie …, 2019 - Wiley Online Library
One of the biggest challenges in the field of nanomedicine is the adsorption of biomolecules
on the nanomaterial upon contact with a biological medium. The interactions of the resulting …

Protein corona formation for nanomaterials and proteins of a similar size: hard or soft corona?

W Liu, J Rose, S Plantevin, M Auffan, JY Bottero… - Nanoscale, 2013 - pubs.rsc.org
Nanoparticles (NPs) entering a biological fluid undergo surface modification due to dynamic,
physicochemical interactions with biological components, especially proteins. In this work …

[HTML][HTML] Hard and soft protein corona of nanomaterials: Analysis and relevance

R García-Álvarez, M Vallet-Regí - Nanomaterials, 2021 - mdpi.com
Upon contact with a biological milieu, nanomaterials tend to interact with biomolecules
present in the media, especially proteins, leading to the formation of the so-called “protein …

Exploiting the novel properties of protein coronas: emerging applications in nanomedicine

K Hamad-Schifferli - Nanomedicine, 2015 - Future Medicine
Protein coronas have been the focus of a great deal of study recently due to their inevitable
formation and their impact on the biological consequences of nanomaterials. Although the …

The protein corona on nanoparticles as viewed from a nanoparticle‐sizing perspective

H Wang, Y Lin, K Nienhaus… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
Most surfaces of engineered nanoparticles (NPs) are reactive toward biomolecules.
Therefore, whenever NPs become immersed in biological fluids, proteins and other …