Cortactin, a member of the actin-binding protein family, plays an important role in cell
movement involving the cytoskeleton, as cell movement mediated by cortactin may induce …

Cortactin is a ubiquitous actin-binding protein that was originally identified as a substrate for
the protein kinase Src. It is accumulated in peripheral, actin-enriched structures of cells …

Cortactin is an actin-binding protein that is overexpressed in many cancers and is a
substrate for both tyrosine and serine/threonine kinases. Tyrosine phosphorylation of …

Cortactin is a cytoskeletal protein and src kinase substrate that is frequently overexpressed
in cancer. Animal studies suggest that cortactin overexpression increases tumor …

Since its discovery in the early 1990's, cortactin has emerged as a key signaling protein in
many cellular processes, including cell adhesion, migration, endocytosis, and tumor …

Cortactin is an F-actin binding protein that stabilizes F-actin networks and promotes actin
polymerization by activating the Arp2/3 complex. Overexpression of cortactin, as observed in …

Cortactin, a substrate of sarcoma (Src) kinases, is an actin-binding protein that is involved in
cytoskeletal regulation, and is frequently overexpressed in cancer cells. Binding to the actin …

Weaver, 2008). Cortactin was first identified as a prominent substrate of the Src nonreceptor
tyrosine kinase. Its name was derived from the observation that cortactin localizes to cortical …

Cortactin is a multidomain actin-binding protein important for the functions of cytoskeleton by
regulating cortical actin dynamics. It is involved in a diverse array of basic cellular functions …

Cortactin is an F-actin binding protein, regulating cell movement and adhesive junction
assembly. However, the function of cortactin in epithelial-mesenchymal transition (EMT) …