[HTML][HTML] Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling
Background Chronic psychological stress is associated with accelerated aging and
increased risk for aging-related diseases, but the underlying molecular mechanisms are …
increased risk for aging-related diseases, but the underlying molecular mechanisms are …
Life stress, glucocorticoid signaling, and the aging epigenome: Implications for aging-related diseases
Life stress has been associated with accelerated cellular aging and increased risk for
developing aging-related diseases; however, the underlying molecular mechanisms remain …
developing aging-related diseases; however, the underlying molecular mechanisms remain …
Psychosocial stress and epigenetic aging
H Palma-Gudiel, L Fañanás, S Horvath… - International review of …, 2020 - Elsevier
Aging is the single most important risk factor for diseases that are currently the leading
causes of morbidity and mortality. However, there is considerable inter-individual variability …
causes of morbidity and mortality. However, there is considerable inter-individual variability …
[HTML][HTML] Accelerated DNA methylation age in adolescent girls: associations with elevated diurnal cortisol and reduced hippocampal volume
Numerous studies have linked exposure to stress to adverse health outcomes through the
effects of cortisol, a product of the stress response system, on cellular aging processes …
effects of cortisol, a product of the stress response system, on cellular aging processes …
Epigenetics as a key link between psychosocial stress and aging: concepts, evidence, mechanisms
AS Zannas - Dialogues in clinical neuroscience, 2019 - Taylor & Francis
Psychosocial stress—especially when chronic, excessive, or occurring early in life—has
been associated with accelerated aging and increased disease risk. With rapid aging of the …
been associated with accelerated aging and increased disease risk. With rapid aging of the …
[HTML][HTML] Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
DL McCartney, JL Min, RC Richmond, AT Lu… - Genome biology, 2021 - Springer
Background Biological aging estimators derived from DNA methylation data are heritable
and correlate with morbidity and mortality. Consequently, identification of genetic and …
and correlate with morbidity and mortality. Consequently, identification of genetic and …
[HTML][HTML] Early environments, stress, and the epigenetics of human health
CJ Mulligan - Annual Review of Anthropology, 2016 - annualreviews.org
The field of social and behavioral epigenetics examines the role of epigenetic modifications
to mediate the effect of psychosocial stressors on an individual's health and well-being …
to mediate the effect of psychosocial stressors on an individual's health and well-being …
Causality-enriched epigenetic age uncouples damage and adaptation
Abstract Machine learning models based on DNA methylation data can predict biological
age but often lack causal insights. By harnessing large-scale genetic data through …
age but often lack causal insights. By harnessing large-scale genetic data through …
[HTML][HTML] Psychological and biological resilience modulates the effects of stress on epigenetic aging
Our society is experiencing more stress than ever before, leading to both negative
psychiatric and physical outcomes. Chronic stress is linked to negative long-term health …
psychiatric and physical outcomes. Chronic stress is linked to negative long-term health …
[HTML][HTML] The transcriptional landscape of age in human peripheral blood
MJ Peters, R Joehanes, LC Pilling… - Nature …, 2015 - nature.com
Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …
to increased disease susceptibility remain inadequately understood. Here we perform a …