Decades of research have characterized diverse immune cells surveilling the CNS. More
recently, the discovery of osseous channels (so-called 'skull channels') connecting the …

It remains unclear how immune cells from skull bone marrow niches are recruited to the
meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via …

Innate immune cells recruited to inflammatory sites have short life spans and originate from
the marrow, which is distributed throughout the long and flat bones. While bone marrow …

INTRODUCTION Myeloid cells are highly heterogeneous, with distinct ontogenies and
immune functions. The diverse role of myeloid populations, including monocytes …

The diploë region of skull has recently been discovered to act as a myeloid cell reservoir to
the underlying meninges. The presence of ossified vascular channels traversing the inner …

The meninges of the brain are an important component of neuroinflammatory response.
Diverse immune cells move from the calvaria marrow into the dura mater via recently …

The bone marrow in the skull is important for shaping immune responses in the brain and
meninges, but its molecular makeup among bones and relevance in human diseases …

Two recent papers reveal that the brain can regulate its own immune responses by sending
molecular cues to immune cells in the skull bone marrow via the cerebrospinal fluid …

Ongoing research is revealing multiple, previously unappreciated, facets of immunity in the
central nervous system, and the recent studies on the meningeal lymphatic system represent …

Discoveries leading to an improved understanding of immune surveillance of the central
nervous system (CNS) have repeatedly provoked dismissal of the existence of immune …