We proteotyped blood plasma from 30 mouse knockout strains and corresponding wild-type
mice from the International Mouse Phenotyping Consortium. We used targeted proteomics …

Motivation Laboratory mouse is the most used animal model in biological research, largely
due to its high conserved synteny with human. Researchers use mice to answer various …

To better understand sex differences in human health and disease, we conducted a
systematic, large-scale investigation of sex differences in the genetic regulation of the …

Cells contain a large yet, constant genome, which contains all the coding information
necessary to sustain cellular physiology. However, proteins are the end products of genes …

Mice have close genetic/physiological relationships to humans, breed rapidly, and can be
genetically modified, making them the most used mammal in biomedical research. Because …

Genetically diverse mouse populations are powerful tools for characterizing the regulation of
the proteome and its relationship to whole-organism phenotypes. We used mass …

The molecular dissections of the mechanistic pathways involved in human disease have
always relied on the use of model organisms. Among the higher mammalian organisms, the …

Experimentation and observation of animal biology is fundamental for our understanding of
human biology, health and disease. Documented history of animal models date back to …

With the rapid assimilation of genomic information and the equally impressive developments
in the field of proteomics, there is an unprecedented interest in biomarker discovery …

Delineating human cardiac pathologies and their basic molecular mechanisms relies on
research conducted in model organisms. Yet translating findings from preclinical models to …