Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration

WG La, M Jin, S Park, HH Yoon, GJ Jeong… - International journal …, 2014 - Taylor & Francis
In this study, we demonstrate that graphene oxide (GO) can be used for the delivery of bone
morphogenetic protein-2 (BMP-2) and substance P (SP), and that this delivery promotes …

Enhancing cell proliferation and osteogenic differentiation of MC3T3-E1 pre-osteoblasts by BMP-2 delivery in graphene oxide-incorporated PLGA/HA biodegradable …

C Fu, X Yang, S Tan, L Song - Scientific reports, 2017 - nature.com
Lack of bioactivity has seriously restricted the development of biodegradable implants for
bone tissue engineering. Therefore, surface modification of the composite is crucial to …

Bone morphogenetic protein-2 for bone regeneration–Dose reduction through graphene oxide-based delivery

WG La, MJ Jung, JK Yoon, SH Bhang, HK Jang, TJ Lee… - Carbon, 2014 - Elsevier
High doses of bone morphogenetic protein-2 (BMP-2) are required for effective bone
regeneration. However, these high doses often cause undesirable adverse effects, including …

Delivery of a therapeutic protein for bone regeneration from a substrate coated with graphene oxide

WG La, S Park, HH Yoon, GJ Jeong, TJ Lee, SH Bhang… - Small, 2013 - Wiley Online Library
The therapeutic efficacy of drugs often depends on the drug delivery carrier. For efficient
delivery of therapeutic proteins, delivery carriers should enable the loading of large doses …

Graphene oxide scaffold accelerates cellular proliferative response and alveolar bone healing of tooth extraction socket

E Nishida, H Miyaji, A Kato, H Takita… - International journal …, 2016 - Taylor & Francis
Graphene oxide (GO) consisting of a carbon monolayer has been widely investigated for
tissue engineering platforms because of its unique properties. For this study, we fabricated a …

Graphene nanoparticles as osteoinductive and osteoconductive platform for stem cell and bone regeneration

H Elkhenany, S Bourdo, S Hecht, R Donnell… - … , Biology and Medicine, 2017 - Elsevier
The potential of graphene-based nanoparticles (GNPs) has recently gained significant
attention in biomedicine, especially in tissue engineering. In this study, we investigated the …

[HTML][HTML] Biocompatible reduced graphene oxide stimulated BMSCs induce acceleration of bone remodeling and orthodontic tooth movement through promotion on …

D Jiao, J Wang, W Yu, K Zhang, N Zhang, L Cao… - Bioactive Materials, 2022 - Elsevier
We has synthesized the biocompatible gelatin reduced graphene oxide (GOG) in previous
research, and in this study we would further evaluate its effects on bone remodeling in the …

Enhanced osteogenesis by reduced graphene oxide/hydroxyapatite nanocomposites

JH Lee, YC Shin, SM Lee, OS Jin, SH Kang… - Scientific reports, 2015 - nature.com
Recently, graphene-based nanomaterials, in the form of two dimensional substrates or three
dimensional foams, have attracted considerable attention as bioactive scaffolds to promote …

Graphene oxide‐copper Nanocomposite‐coated porous CaP scaffold for vascularized bone regeneration via activation of Hif‐1α

W Zhang, Q Chang, L Xu, G Li, G Yang… - Advanced …, 2016 - Wiley Online Library
Graphene has been studied for its in vitro osteoinductive capacity. However, the in vivo bone
repair effects of graphene‐based scaffolds remain unknown. The aqueous soluble …

Stimulated osteogenic differentiation of human mesenchymal stem cells by reduced graphene oxide

L Jin, JH Lee, OS Jin, YC Shin, MJ Kim… - … of nanoscience and …, 2015 - ingentaconnect.com
Osteoprogenitor cells play a significant role in the growth or repair of bones, and have great
potential as cell sources for regenerative medicine and bone tissue engineering, but control …