Rapidly growing malignant tumors frequently encounter hypoxia and nutrient (eg, glucose)
deprivation, which occurs because of insufficient blood supply. This results in necrotic cell …

A number of cell death pathways have been recognized. Though apoptosis and autophagy
have been well characterized, programmed necrosis has recently received attention and …

Great efforts have been made in revealing the mechanisms governing cancer resistance
and recurrence. The in-situ effects of cell death, caused by hypoxia and metabolic stress …

Hypoxia is often found in solid tumors and is associated with tumor progression and poor
clinical outcomes. The exact mechanisms related to hypoxia‐induced invasion and …

Until recently, necrosis, unlike apoptosis, was considered as passive and unregulated form
of cell death. However, during the last decade a number of experimental data demonstrated …

The treatment of tumors requires the induction of cell death. Radiotherapy, chemotherapy,
and immunotherapy are administered to kill cancer cells; however, some cancer cells are …

Tumor necrosis is a common histological feature and poor prognostic predictor in various
cancers. Despite its significant clinical implications, the mechanism underlying tumor …

Hypoxia is a hallmark of cancer that is strongly associated with invasion, metastasis,
resistance to therapy and poor clinical outcome. Tumour hypoxia affects immune responses …

Dysregulation of apoptosis is associated with the development of human cancer and
resistance to anticancer therapy. We have previously shown in tumor xenografts that DNA …

The functional relationship and cross-regulation between autophagy and apoptosis is
complex. In this study we show that the high-mobility group box 1 protein (HMGB1) is a …