The adhesive interactions of cells with their environment through the integrin family of
transmembrane receptors have key roles in regulating multiple aspects of cellular …

A detailed depiction of the'integrin adhesome', consisting of a complex network of 156
components linked together and modified by 690 interactions is presented. Different views of …

The adhesion nexus is the site at which integrin receptors bridge intracellular cytoskeletal
and extracellular matrix networks. The connection between integrins and the cytoskeleton is …

Cell biologists studying cell adhesion have already figured out that cell–extracellular matrix
connections, mediated by integrin receptors, are diverse and extremely complex structures …

Adhesion sites, which interconnect cells with their neighbors or with the extracellular matrix
(ECM), are large multiprotein complexes that provide mechanical coupling as well as a …

Cell adhesions mediate important bidirectional interactions between cells and the
extracellular matrix. They provide an interactive interface between the extracellular chemical …

Integrin receptor activation initiates the formation of integrin adhesion complexes (IACs) at
the cell membrane that transduce adhesion-dependent signals to control a multitude of …

Integrins are heterodimeric transmembrane receptors that connect the extracellular matrix
environment to the actin cytoskeleton via adaptor molecules through assembly of a range of …

Integrin adhesion complexes (IACs) have evolved over millions of years to integrate
metazoan cells physically with their microenvironment. It is presumed that the simultaneous …

Integrins are ubiquitously expressed cell surface receptors that play a critical role in
regulating the interaction between a cell and its microenvironment to control cell fate. These …