Two decades of studies in multiple model organisms have established the Hippo pathway
as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ …

How the organ size is adjusted to the proper size during development and how organs know
that they reach the original size during regeneration remain long-standing questions. Based …

The Hippo signaling pathway is gaining recognition as an important player in both organ
size control and tumorigenesis, which are physiological and pathological processes that …

In the past decades, the Hippo signaling pathway has been delineated and shown to play
multiple roles in the control of organ size in both Drosophila and mammals. In mammals, the …

The control of cell division is essential for normal development and the maintenance of
cellular homeostasis. Abnormal cell proliferation is associated with multiple pathological …

The control of organ size is a basic biological question. In the past several years, the Hippo
signaling pathway has been delineated and shown to be crucial in control of organ size in …

How the organs of multicellular organisms develop to a pre-defined size is a fundamental
question in biology, but little is known about the underlying mechanisms. In the past decade …

Hippo pathway was initially identified through genetic screens for genes regulating organ
size in fruitflies. Recent studies have highlighted the role of Hippo signaling as a key …

Understanding the molecular nature of human cancer is essential to the development of
effective and personalized therapies. Several different molecular signal transduction …

The biological significance and deregulation of the Hippo pathway during organ growth and
tumorigenesis have received a surge of interest in the past decade. The Hippo pathway core …