Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases

AG Wu, XG Zhou, G Qiao, LU Yu, Y Tang, LU Yan… - Ageing research …, 2021 - Elsevier
Neuroinflammation is considered as a detrimental factor in neurodegenerative diseases,
including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) …

[HTML][HTML] Key mechanisms and potential targets of the NLRP3 inflammasome in neurodegenerative diseases

Y Guan, F Han - Frontiers in Integrative Neuroscience, 2020 - frontiersin.org
Neurodegenerative diseases are neuronal disorders characterized by the loss of a large
number of neurons in the human brain. Innate immunity-mediated neuroinflammation …

The role of dopamine in NLRP3 inflammasome inhibition: Implications for neurodegenerative diseases

E Possemato, L La Barbera, A Nobili, P Krashia… - Ageing Research …, 2023 - Elsevier
Abstract In the Central Nervous System (CNS), neuroinflammation orchestrated by microglia
and astrocytes is an innate immune response to counteract stressful and dangerous insults …

Targeting NLRP3 inflammasome for neurodegenerative disorders

J Yao, Z Wang, W Song, Y Zhang - Molecular psychiatry, 2023 - nature.com
Neuroinflammation is a key pathological feature in neurological diseases, including
Alzheimer's disease (AD). The nucleotide-binding domain leucine-rich repeat-containing …

[HTML][HTML] The role of NLRP3 inflammasome in Alzheimer's disease and potential therapeutic targets

T Liang, Y Zhang, S Wu, Q Chen, L Wang - Frontiers in Pharmacology, 2022 - frontiersin.org
Alzheimer's disease (AD) is a common age-related neurodegenerative disease
characterized by progressive cognitive dysfunction and behavioral impairment. The typical …

Mechanistic and therapeutic role of NLRP3 inflammasome in the pathogenesis of Alzheimer's disease

D Jha, ENTP Bakker, R Kumar - Journal of neurochemistry, 2023 - Wiley Online Library
Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, has emerged
as the most common form of dementia in the elderly. Several pathological hallmarks have …

Mechanisms of NLRP3 inflammasome activation: its role in the treatment of Alzheimer's disease

Y Zhang, Y Zhao, J Zhang, G Yang - Neurochemical Research, 2020 - Springer
Alzheimer's disease (AD) is a common neurodegenerative disease of progressive dementia
which is characterized pathologically by extracellular neuritic plaques containing …

[HTML][HTML] Neurodegenerative disease and the NLRP3 inflammasome

JA Holbrook, HH Jarosz-Griffiths, E Caseley… - Frontiers in …, 2021 - frontiersin.org
The prevalence of neurodegenerative disease has increased significantly in recent years,
and with a rapidly aging global population, this trend is expected to continue. These …

[HTML][HTML] The role of the effects of autophagy on NLRP3 inflammasome in inflammatory nervous system diseases

S Zhao, X Li, J Wang, H Wang - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Autophagy is a stable self-sustaining process in eukaryotic cells. In this process, pathogens,
abnormal proteins, and organelles are encapsulated by a bilayer membrane to form …

[HTML][HTML] The involvement of NLRP3 inflammasome in the treatment of neurodegenerative diseases

YS Feng, ZX Tan, LY Wu, F Dong, F Zhang - Biomedicine & …, 2021 - Elsevier
In an ageing society, neurodegenerative diseases have attracted attention because of their
high incidence worldwide. Despite extensive research, there is a lack of conclusive insights …