A call to arms: quest for a cryptococcal vaccine

MCC Van Dyke, FL Wormley - Trends in microbiology, 2018 - cell.com
Cryptococcosis remains a significant cause of morbidity and mortality world-wide,
particularly among AIDS patients. Yet, to date, there are no licensed vaccines clinically …

Cryptococcus antigens and immune responses: implications for a vaccine

AK Chaturvedi, FL Wormley Jr - Expert review of vaccines, 2013 - Taylor & Francis
Cryptococcosis is a fungal disease primarily occurring in immunocompromised individuals,
such as AIDS patients, and is associated with high morbidity and mortality. However …

[HTML][HTML] Vaccine and immunotherapeutic approaches for the prevention of cryptococcosis: lessons learned from animal models

CR Hole, FL Wormley Jr - Frontiers in microbiology, 2012 - frontiersin.org
Cryptococcus neoformans and C. gattii, the predominant etiological agents of
cryptococcosis, can cause life-threatening infections of the central nervous system in …

[HTML][HTML] Is Development of a Vaccine against Cryptococcus neoformans Feasible?

CM Leopold Wager, FL Wormley Jr - PLoS pathogens, 2015 - journals.plos.org
Cryptococcus neoformans, the predominant etiological agent of cryptococcosis, is an
encapsulated fungal pathogen that can cause fungal pneumonia and life-threatening …

[HTML][HTML] Host populations, challenges, and commercialization of cryptococcal vaccines

M Del Poeta, FL Wormley Jr, X Lin - PLoS Pathogens, 2023 - journals.plos.org
Vaccines are one of the most effective public health tools to prevent and manage infectious
diseases. Since the first clinical use of vaccines in the late 18th century, many vaccines have …

[HTML][HTML] Induction of protective immunity against cryptococcosis

KL Wozniak, S Hardison, M Olszewski, FL Wormley - Mycopathologia, 2012 - Springer
Cryptococcus neoformans, the predominant etiological agent of cryptococcosis, is an
encapsulated fungal pathogen that can cause life-threatening infections of the central …

[PDF][PDF] Vaccination with recombinant Cryptococcus proteins in glucan particles protects mice against cryptococcosis in a manner dependent upon mouse strain and …

CA Specht, CK Lee, H Huang, MM Hester, J Liu… - 2017 - core.ac.uk
Development of a vaccine to protect against cryptococcosis is a priority given the enormous
global burden of disease in at-risk individuals. Using glucan particles (GPs) as a delivery …

Innate host defenses against Cryptococcus neoformans

C Hole, FL Wormley - Journal of Microbiology, 2016 - Springer
Cryptococcus neoformans, the predominant etiological agent of cryptococcosis, can cause
life-threatening infections of the central nervous system in immunocompromised and …

[HTML][HTML] Induction of Broad-Spectrum Protective Immunity against Disparate Cryptococcus Serotypes

MCC Van Dyke, AK Chaturvedi, SE Hardison… - Frontiers in …, 2017 - frontiersin.org
Cryptococcosis is a fungal disease caused by multiple Cryptococcus serotypes; particularly
C. neoformans (serotypes A and D) and C. gattii (serotypes B and C). To date, there is no …

Vaccination with Recombinant Cryptococcus Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and …

CA Specht, CK Lee, H Huang, MM Hester, J Liu… - MBio, 2017 - Am Soc Microbiol
Development of a vaccine to protect against cryptococcosis is a priority given the enormous
global burden of disease in at-risk individuals. Using glucan particles (GPs) as a delivery …