Dentin can be described as a biological composite with collagen matrix embedded with
nanosized hydroxyapatite mineral crystallites. Matrix metalloproteinases (MMPs) and …

Dentin organic matrix, with type I collagen as the main component, is exposed after
demineralization in dentinal caries, erosion or acidic conditioning during adhesive …

OBJECTIVES: Contemporary adhesives lose their bond strength to dentin regardless of the
bonding system used. This loss relates to the hydrolysis of collagen matrix of the hybrid …

Degradation of dentin matrix components within caries dentin has been correlated with the
activity of host-derived proteases, such as matrix metalloproteases (MMPs) and cysteine …

The limited durability of resin-dentin bonds severely compromises the lifetime of tooth-
colored restorations. Bond degradation occurs via hydrolysis of suboptimally polymerized …

This review examines the fundamental processes responsible for the aging mechanisms
involved in the degradation of resin‐bonded interfaces, as well as some potential …

This review describes the relationship between dentin collagen hybrid bond layer
degradation and the Matrix Metalloproteinases (MMPs) after their release by acid etch and …

Dentin matrix metalloproteinases (MMPs) are a family of host‐derived proteolytic enzymes
trapped within mineralized dentin matrix, which have the ability to hydrolyze the organic …

Auto-degradation of collagen matrices occurs within hybrid layers created by contemporary
dentin bonding systems, by the slow action of host-derived matrix metalloproteinases …

The objective of this review is to summarize our understanding of the role of host matrix
metalloproteinases (MMPs) in the caries process and to discuss new therapeutic avenues …