Hanahan and Weinberg have proposed 10 organizing principles that enable growth and
metastatic dissemination of cancer cells. These distinctive and complementary capabilities …

Tumor cells corrupt surrounding normal cells instructing them to support proliferative, pro-
angiogenic and immunosuppressive networks that favor tumorigenesis and metastasis. This …

Galectins play a key role in oncogenic processes. Although several galectins are known,
their relative expression at the mRNA and protein levels, the subcellular localization, and …

Galectins are a family of carbohydrate binding proteins with a broad range of cytokine and
growth factor-like functions in multiple steps of cancer progression. They contribute to tumor …

Highlights•Galectins engage a number of glycosylated immune checkpoint
receptors.•Galectins alter T-cell and NK-cell activation, signaling and survival.•Galectins …

Galectins are a family of animal lectins with diverse biological activities. They function both
extracellularly, by interacting with cell-surface and extracellular matrix glycoproteins and …

Along with the discovery of tumor-driven inflammatory pathways, there has been a
considerable progress over the past 10 years in understanding the mechanisms leading to …

Galectin-3 is a member of the β-galactoside-binding lectin family, whose expression is often
dysregulated in cancers. While galectin-3 is usually an intracellular protein found in the …

Galectins are small proteins with pleiotropic functions, which depend on both their lectin
(glycan recognition) and non-lectin (recognition of other biomolecules besides glycans) …

Galectins are a family of small, highly conserved, molecular effectors that mediate various
biological processes, including chemotaxis and angiogenesis, and that function by …