Acute myeloid leukaemia is a fatal disease for most patients. We have found that ferumoxytol
(Feraheme), an FDA-approved iron oxide nanoparticle for iron deficiency treatment …

Until now, the Food and Drug Administration (FDA)-approved iron supplement ferumoxytol
and other iron oxide nanoparticles have been used for treating iron deficiency, as contrast …

Since its discovery more than 85 years ago, ferritin has principally been known as an iron
storage protein. However, new roles, beyond iron storage, are being uncovered. Novel …

Ferumoxytol is an intravenous iron oxide nanoparticle formulation that has been approved
by the US Food and Drug Administration (FDA) for treating anemia in patients with chronic …

Mounting evidence suggest that iron overload enhances cancer growth and metastasis;
hence, iron chelation is being increasingly used as part of the treatment regimen in patients …

Ferritin, a major iron storage protein found in most living organisms, is composed of a 24‐
subunit protein cage with a hollow interior cavity. Serum ferritin serves as a critical marker to …

Iron is an essential dietary element. However, the ability of iron to cycle between oxidized
and reduced forms also renders it capable of contributing to free radical formation, which …

IONP (iron oxide nanoparticles) commercialized for treatments of iron anemia or cancer
diseases can be administered at doses exceeding 1 g per patient, indicating their bio …

Ferroportin (FPN), the only known vertebrate iron exporter, transports iron from intestinal,
splenic, and hepatic cells into the blood to provide iron to other tissues and cells in vivo …

Conspectus Ferritins are spherical iron storage proteins within cells that are composed of a
combination of 24 subunits of two types, heavy-chain ferritin (HFn) and light-chain ferritin …