An efficient Th1-driven adaptive immune response requires activation of the T cell receptor
and secretion of the T cell stimulatory cytokine IL-12 by activated antigen-presenting cells. IL …

IL-27, a novel heterodimeric cytokine produced by antigen-presenting cells, signals through
the T cell cytokine receptor (TCCR)/WSX-1 expressed on naïve CD4+ T cells and natural …

IL-27 is formed by the association of a cytokine subunit, p28, with the soluble cytokine
receptor EBV-induced gene 3 (EBI3). The IL-27R comprises gp130 and WSX-1. The marked …

The recently discovered cytokine IL-27 belongs to the IL-6/IL-12 family of cytokines and
induced proliferation of naive CD4+ T cells and the generation of a Th1-type adaptive …

IL-21, the most recently described member of the common γ-chain cytokine family, is
produced by activated CD4 T cells, whereas CD8 T cells express the IL-21 receptor. To …

Although the ability of IL-27 to promote T cell responses is well documented, the anti-
inflammatory properties of this cytokine remain poorly understood. The current work …

IL-27 is a novel IL-6/IL-12 family cytokine that is considered to play a role in Th1
differentiation, whereas the exact role of IL-27 in Th1 differentiation and its molecular …

IL-27 is a novel IL-12 family member that plays a role in the early regulation of Th1 initiation.
However, its role in B cells remains unexplored. We here show a role for IL-27 in the …

IL-27 is a novel heterodimeric cytokine of the IL-12 family that plays an important role in the
regulation of T cell responses. Its role on human B cells has not been previously studied. In …

Interleukin-27 (IL-27) supports proliferation of naive CD4+ T cells and enhances interferon-γ
(IFN-γ) production by activated T cells and natural killer (NK) cells. We report here that IL-27 …