Malaria medicines: a glass half full?
TNC Wells, RH Van Huijsduijnen… - Nature Reviews Drug …, 2015 - nature.com
Despite substantial scientific progress over the past two decades, malaria remains a
worldwide burden that causes hundreds of thousands of deaths every year. New, affordable …
worldwide burden that causes hundreds of thousands of deaths every year. New, affordable …
[HTML][HTML] Recent advances in malaria drug discovery
MA Biamonte, J Wanner, KG Le Roch - Bioorganic & medicinal chemistry …, 2013 - Elsevier
This digest covers some of the most relevant progress in malaria drug discovery published
between 2010 and 2012. There is an urgent need to develop new antimalarial drugs. Such …
between 2010 and 2012. There is an urgent need to develop new antimalarial drugs. Such …
Antimalarial drug discovery–the path towards eradication
JN Burrows, E Burlot, B Campo, S Cherbuin… - Parasitology, 2014 - cambridge.org
Malaria is a disease that still affects a significant proportion of the global human population.
Whilst advances have been made in lowering the numbers of cases and deaths, it is clear …
Whilst advances have been made in lowering the numbers of cases and deaths, it is clear …
The antimalarial pipeline
RH van Huijsduijnen, TNC Wells - Current opinion in pharmacology, 2018 - Elsevier
Highlights•The antimalarial pipeline has been enriched with new molecules and
targets.•The antimalarial target compound and product profiles have been redefined.•In …
targets.•The antimalarial target compound and product profiles have been redefined.•In …
The state of the art in anti-malarial drug discovery and development
JN Burrows, K Chibale… - Current topics in medicinal …, 2011 - ingentaconnect.com
Malaria is one of the most prevalent and devastating infectious diseases of our time. Yet,
unfortunately, apart from artemisinin combination therapies there are relatively few effective …
unfortunately, apart from artemisinin combination therapies there are relatively few effective …
Expanding the antimalarial drug arsenal—Now, but how?
BT Grimberg, RK Mehlotra - Pharmaceuticals, 2011 - mdpi.com
The number of available and effective antimalarial drugs is quickly dwindling. This is mainly
because a number of drug resistance-associated mutations in malaria parasite genes, such …
because a number of drug resistance-associated mutations in malaria parasite genes, such …
[HTML][HTML] Drug targets for resistant malaria: historic to future perspectives
New antimalarial targets are the prime need for the discovery of potent drug candidates. In
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …
[HTML][HTML] Antimalarial drug discovery—approaches and progress towards new medicines
EL Flannery, AK Chatterjee, EA Winzeler - Nature Reviews Microbiology, 2013 - nature.com
Malaria elimination has recently been reinstated as a global health priority but current
therapies seem to be insufficient for the task. Elimination efforts require new drug classes …
therapies seem to be insufficient for the task. Elimination efforts require new drug classes …
Antimalarial drug discovery: efficacy models for compound screening
Increased efforts in antimalarial drug discovery are urgently needed. The goal must be to
develop safe and affordable new drugs to counter the spread of malaria parasites that are …
develop safe and affordable new drugs to counter the spread of malaria parasites that are …
The global portfolio of new antimalarial medicines under development
P Olliaro, TNC Wells - Clinical Pharmacology & Therapeutics, 2009 - Wiley Online Library
With the elimination of malaria now considered a realistic goal, it would be useful for
scientists and policy makers to have an inventory of the arsenal of antimalarials, current and …
scientists and policy makers to have an inventory of the arsenal of antimalarials, current and …