Cystic fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane
conductance regulator (CFTR) gene. The major cause of limited life span in CF patients is …

Existing animal models of cystic fibrosis (CF) have provided key insights into CF
pathogenesis but have been limited by short lifespans, absence of key phenotypes, and/or …

The cystic fibrosis (CF) field is the beneficiary of five species of animal models that lack
functional cystic fibrosis transmembrane conductance regulator (CFTR) channel. These …

Animal models of cystic fibrosis (CF) are essential for investigating disease mechanisms and
trialing potential therapeutics. This study generated two CF rat models using clustered …

One of the most revolutionary technologies in recent years in the field of molecular biology is
CRISPR-Cas9. CRISPR technology is a promising tool for gene editing that provides …

Background Genetically engineered animals are essential for gaining a proper
understanding of the disease mechanisms of cystic fibrosis (CF). The rat is a relevant …

Cystic fibrosis (CF) is the most common lethal inherited disease in Caucasians and is
caused by mutations in the CFTR gene. The disease is incurable and medical treatment is …

Nonsense mutations are present in 10% of patients with CF, produce a premature
termination codon in CFTR mRNA causing early termination of translation, and lead to lack …

Cystic Fibrosis (CF) is an autosomal recessive disease caused by mutations in CF
transmembrane conductance regulator (CFTR), resulting in defective anion transport …

Progress toward understanding the pathogenesis of cystic fibrosis (CF) and developing
effective therapies has been hampered by lack of a relevant animal model. CF mice fail to …