Effect of cumulin and super-GDF9 in standard and biphasic mouse IVM

N Akin, D Richani, X Liao, Y Zhao, AC Herta… - Journal of Assisted …, 2022 - Springer
Purpose In vitro maturation (IVM) is a technology that generates mature oocytes following
culture of immature cumulus-oocyte complexes (COC) in vitro. IVM is characterized by …

Capacitation IVM improves cumulus function and oocyte quality in minimally stimulated mice

Y Zhao, X Liao, AE Krysta, MJ Bertoldo… - Journal of Assisted …, 2020 - Springer
Purpose Oocyte in vitro maturation (IVM) is a patient-friendly reproductive technology but
lower success rates than IVF have limited its uptake. Capacitation-IVM (CAPA-IVM) is an …

Effects of lactate, super-GDF9, and low oxygen tension during bi-phasic in vitro maturation on the bioenergetic profiles of mouse cumulus–oocyte complex

N Akin, G Ates, L von Mengden, AC Herta… - Biology of …, 2023 - academic.oup.com
In vitro maturation (IVM) is an alternative assisted reproductive technology with reduced
hormone-related side effects and treatment burden compared to conventional IVF …

Glucose metabolism characterization during mouse in vitro maturation identifies alterations in cumulus cells

N Akin, L von Mengden, AC Herta… - Biology of …, 2021 - academic.oup.com
In vitro maturation (IVM) is an assisted reproduction technique with reduced hormone-
related side-effects. Several attempts to implement IVM in routine practice have failed …

Biphasic in vitro maturation (CAPA-IVM) specifically improves the developmental capacity of oocytes from small antral follicles

F Sanchez, AH Le, VNA Ho, S Romero… - Journal of assisted …, 2019 - Springer
Purpose To investigate the effectiveness of a biphasic IVM culture strategy at improving IVM
outcomes in oocytes from small follicles (< 6 mm) compared with routine Standard IVM in …

The place of in vitro maturation in assisted reproductive technology

LN Vuong, TM Ho, RB Gilchrist, J Smitz - Fertility & Reproduction, 2019 - World Scientific
In vitro maturation (IVM) is an assisted reproductive technology (ART) whereby immature
cumulus-oocyte complexes are collected and matured in vitro, without need for controlled …

Disruption of bidirectional oocyte-cumulus paracrine signaling during in vitro maturation reduces subsequent mouse oocyte developmental competence

CX Yeo, RB Gilchrist, M Lane - Biology of reproduction, 2009 - academic.oup.com
Oocyte-cumulus cell bidirectional communication is essential for normal development of the
oocyte and cumulus cells (CCs) within the follicle. We showed recently that addition of …

In vitro maturation

ML Walls, RJ Hart - Best practice & research Clinical obstetrics & …, 2018 - Elsevier
In vitro maturation (IVM) is an in vitro fertilisation (IVF) technique modified to collect immature
oocytes from antral follicles, with the final stages of meiosis completed during in vitro culture …

The improvement and clinical application of human oocyte in vitro maturation (IVM)

X Gong, H Li, Y Zhao - Reproductive Sciences, 2022 - Springer
Oocyte in vitro maturation (IVM) is a technology with a long history that was established
before IVF. Although it has been studied extensively, the efficiency of IVM has been poor for …

Fibroblast growth factor 2 regulates cumulus differentiation under the control of the oocyte

RG Barros, PF Lima, ACS Soares, L Sanches… - Journal of Assisted …, 2019 - Springer
Purpose We first assessed regulation of FGF2 expression in cumulus cells by FSH and
oocyte-secreted factors during in vitro maturation (IVM). Then, we tested the hypothesis that …