BACKGROUND: There is a large treatment gap in alcohol dependence, and current
treatments are only moderately effective in preventing relapse. New treatment modalities …

This study evaluated the long-term efficacy and safety of nalmefene treatment in reducing
alcohol consumption. We randomised (1: 3) 675 alcohol-dependent patients≥ 18 years of …

This study evaluated the efficacy of as-needed use of the opioid system modulator
nalmefene in reducing alcohol consumption in patients with alcohol dependence. Seven …

Background Nalmefene is a newer opioid antagonist that is structurally similar to naltrexone
but with a number of potential pharmacological advantages for the treatment of alcohol …

Aims Reducing alcohol consumption is one treatment approach for alcohol‐dependent
patients. This study compared nalmefene 20 mg and 10 mg with placebo, combined with …

Background Nalmefene is a recent option in alcohol dependence treatment. Its approval
was controversial. We conducted a systematic review and meta-analysis of the aggregated …

A dozen studies have been published showing that opiate antagonists suppress alcohol
drinking in animals, and two independent placebo‐controlled, double‐blind clinical trials of …

Aims: The aim of the study was to investigate the efficacy and safety of as-needed use of
nalmefene 18 mg versus placebo in reducing alcohol consumption in patients who did not …

Background: Clinical studies with opioid antagonists for treatment of problem drinking have
mainly been conducted in specialized alcohol treatment centers, included structured …

Nalmefene, a mu-and delta-opioid receptor (MOR, DOR) antagonist and a partial kappa-
opioid receptor (KOR) agonist, is approved in the European Union and other countries for …