Urinary extracellular vesicles (uEVs) play important roles in physiologic condition and
various renal/urological disorders. However, their roles in kidney stone disease remain …

Urinary crystals with various sizes are present in healthy individuals and patients with kidney
stone; however, the cellular uptake mechanism of calcium oxalate of various sizes has not …

Background The increasing number of patients suffering from urolithiasis represents one of
the major challenges which nephrologists face worldwide today. For enhancing therapeutic …

Calcium oxalate monohydrate (COM) crystals cause kidney stone disease by still unclear
mechanisms. The present study aimed to characterize changes in secretion of proteins from …

Background The roles of urinary macromolecules (UMMs) in calcium oxalate (CaOx) renal
stone formation have not been consistently established. Aim To unravel these roles using a …

Urinary stone disease is an ailment afflicting human kind for many centuries. It can affect up
to a quarter the population in certain geographic areas and hence poses a significant health …

Better understanding of molecular mechanisms for kidney stone formation is required to
improve management of kidney stone disease with better therapeutic outcome. Recent …

PURPOSE: Adhesion of urinary crystals to renal tubular cells could be a critical event that
triggers a cascade of responses ending in kidney stone formation. We clarified the role of …

Urine pH has been thought to be an important factor that can modulate kidney stone
formation. Nevertheless, there was no systematic evaluation of such pH effect. Our present …

Interaction between calcium oxalate crystals and renal tubular cells has been recognized as
one of the key mechanisms for kidney stone formation. While crystal adhesion and …