Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine
The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome …
harbors a large and diverse microbial population collectively called the gut microbiome …
Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A review in the theme: cellular responses to hypoxia
L Zheng, CJ Kelly, SP Colgan - American Journal of …, 2015 - journals.physiology.org
In recent years, the intestinal mucosa has proven to be an intriguing organ to study tissue
oxygenation. The highly vascularized lamina propria juxtaposed to an anaerobic lumen …
oxygenation. The highly vascularized lamina propria juxtaposed to an anaerobic lumen …
Hypoxia inducible factor-1α: the curator of gut homeostasis
The human gut microbiome is a stratified and resilient ecosystem co-inhabited by a diverse
and dynamic pool of microorganisms. Microbial selection, establishment, and colonization …
and dynamic pool of microorganisms. Microbial selection, establishment, and colonization …
[HTML][HTML] Hypoxia and inflammatory bowel disease
EP Cummins, D Crean - Microbes and infection, 2017 - Elsevier
Inflammatory bowel disease (IBD) is a general term to describe inflammatory diseases of the
gastrointestinal tract such as Crohn's disease and ulcerative colitis. IBD affects …
gastrointestinal tract such as Crohn's disease and ulcerative colitis. IBD affects …
Hypoxia and gastrointestinal disease
The gastrointestinal mucosa is a richly perfused vascular bed directly juxtaposed with the
anaerobic and nonsterile lumen of the gut. As such, intestinal epithelial cells, which line the …
anaerobic and nonsterile lumen of the gut. As such, intestinal epithelial cells, which line the …
Hypoxia-inducible factor as a bridge between healthy barrier function, wound healing, and fibrosis
The healthy mammalian intestine is lined by a single layer of epithelial cells. These cells
provide a selectively permeable barrier to luminal contents and normally do so in an efficient …
provide a selectively permeable barrier to luminal contents and normally do so in an efficient …
Hypoxia: an alarm signal during intestinal inflammation
Intestinal epithelial cells that line the mucosal surface of the gastrointestinal tract are
positioned between an anaerobic lumen and a highly metabolic lamina propria. As a result …
positioned between an anaerobic lumen and a highly metabolic lamina propria. As a result …
Hypoxia and metabolic factors that influence inflammatory bowel disease pathogenesis
LE Glover, SP Colgan - Gastroenterology, 2011 - Elsevier
The gastrointestinal epithelium is anatomically positioned to provide a selective barrier
between the anaerobic lumen and lamina propria, which has a high rate of metabolism …
between the anaerobic lumen and lamina propria, which has a high rate of metabolism …
Role of intestinal HIF-2α in health and disease
SK Ramakrishnan, YM Shah - Annual review of physiology, 2016 - annualreviews.org
The intestine is supported by a complex vascular system that undergoes dynamic and
transient daily shifts in blood perfusion, depending on the metabolic state. Moreover, the …
transient daily shifts in blood perfusion, depending on the metabolic state. Moreover, the …
Hypoxia and HIF-1 as key regulators of gut microbiota and host interactions
Oxygen (O 2) availability is a key factor regulating microbiota composition and the
homeostatic function of cells in the intestinal mucosa of vertebrates. Microbiota-derived …
homeostatic function of cells in the intestinal mucosa of vertebrates. Microbiota-derived …