The metanephric kidney is a mesodermal organ that develops as a result of reciprocal
interactions between the ureteric bud and the blastema. The generation of embryonic stem …

Embryonic stem (ES) cells have been induced to differentiate in vitro into a broad spectrum
of specialized cell types, including hematopoietic, pancreatic, and neuronal cell types. Such …

Many stages of nephrogenesis can be studied using cultured embryonic kidneys, but there
is no efficient technique available to readily knockdown or overexpress transgenes for rapid …

The kidney is formed from two tissue populations derived from the intermediate mesoderm,
the ureteric bud, and the metanephric mesenchyme. Metanephric mesenchyme is a …

Renal cells are used in basic research, disease models, tissue engineering, drug screening,
and in vitro toxicology. In order to provide a reliable source of human renal cells, we …

A tissue stem cell should exhibit long-term self-renewal, clonogenicity and a capacity to
differentiate into the tissue of origin. Such a postnatal renal stem cell has not been formally …

Differentiation of mouse embryonic stem (ES) cells via embryoid bodies (EB) is established
as a suitable model to study cellular processes of development in vitro. ES cells are known …

The in vitro derivation of renal lineage progenitor cells is essential for renal cell therapy and
regeneration. Despite extensive studies in the past, a protocol for renal lineage induction …

Ureteric bud epithelial cells and metanephric mesenchymal cells that comprise the
metanephric kidney primordium are capable of producing nephrons and collecting ducts …

Nephron progenitors in the embryonic kidney propagate while generating differentiated
nephrons. However, in mice, the progenitors terminally differentiate shortly after birth. Here …