Neurexins: molecular codes for shaping neuronal synapses
AM Gomez, L Traunmüller, P Scheiffele - Nature Reviews …, 2021 - nature.com
The function of neuronal circuits relies on the properties of individual neuronal cells and
their synapses. We propose that a substantial degree of synapse formation and function is …
their synapses. We propose that a substantial degree of synapse formation and function is …
[HTML][HTML] Synaptic neurexin complexes: a molecular code for the logic of neural circuits
TC Südhof - Cell, 2017 - cell.com
Synapses are specialized junctions between neurons in brain that transmit and compute
information, thereby connecting neurons into millions of overlapping and interdigitated …
information, thereby connecting neurons into millions of overlapping and interdigitated …
Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing
K Tabuchi, TC Südhof - Genomics, 2002 - Elsevier
Neurexins are neuron-specific vertebrate proteins with hundreds of differentially spliced
isoforms that may function in synapse organization. We now show that Drosophila …
isoforms that may function in synapse organization. We now show that Drosophila …
Neurexins: three genes and 1001 products
M Missler, TC Südhof - Trends in Genetics, 1998 - cell.com
The human brain has approximately 10 12 neurons, three orders of magnitude more than
there are basepairs in the human genome. Each neuron is connected to other neurons by …
there are basepairs in the human genome. Each neuron is connected to other neurons by …
[HTML][HTML] Single-cell mRNA profiling reveals cell-type-specific expression of neurexin isoforms
Neurexins are considered central organizers of synapse architecture that are implicated in
neuropsychiatric disorders. Expression of neurexins in hundreds of alternatively spliced …
neuropsychiatric disorders. Expression of neurexins in hundreds of alternatively spliced …
[HTML][HTML] Conditional deletion of all neurexins defines diversity of essential synaptic organizer functions for neurexins
Neurexins are recognized as key organizers of synapses that are essential for normal brain
function. However, it is unclear whether neurexins are fundamental building blocks of all …
function. However, it is unclear whether neurexins are fundamental building blocks of all …
Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity
The neurexins are neuronal proteins that function as cell adhesion molecules during
synaptogenesis and in intercellular signaling. Although mammalian genomes contain only …
synaptogenesis and in intercellular signaling. Although mammalian genomes contain only …
Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses
Abstract α-and β-neurexins are presynaptic cell-adhesion molecules whose general
importance for synaptic transmission is well documented. The specific functions of …
importance for synaptic transmission is well documented. The specific functions of …
[HTML][HTML] Targeted combinatorial alternative splicing generates brain region-specific repertoires of neurexins
Molecular diversity of surface receptors has been hypothesized to provide a mechanism for
selective synaptic connectivity. Neurexins are highly diversified receptors that drive the …
selective synaptic connectivity. Neurexins are highly diversified receptors that drive the …
Emerging evidence implicating a role for neurexins in neurodegenerative and neuropsychiatric disorders
Synaptopathies are brain disorders characterized by dysfunctional synapses, which are
specialized junctions between neurons that are essential for the transmission of information …
specialized junctions between neurons that are essential for the transmission of information …