New strategies and mechanisms for targeting Streptococcus mutans biofilm formation to prevent dental caries: a review

Z Gao, X Chen, C Wang, J Song, J Xu, X Liu… - Microbiological …, 2023 - Elsevier
Dental caries, a prevalent oral infectious disease, is intricately linked to the biofilm formation
on the tooth surfaces by oral microbes. Among these, Streptococcus mutans plays a central …

Targeted antimicrobial therapy against Streptococcus mutans establishes protective non‐cariogenic oral biofilms and reduces subsequent infection

L Li, L Guo, R Lux, R Eckert, D Yarbrough… - International journal of …, 2010 - nature.com
Aim Dental biofilms are complex communities composed largely of harmless bacteria.
Certain pathogenic species including Streptococcus mutans (S. mutans) can become …

Targeting of Streptococcus mutans Biofilms by a Novel Small Molecule Prevents Dental Caries and Preserves the Oral Microbiome

SS Garcia, MS Blackledge, S Michalek… - Journal of dental …, 2017 - journals.sagepub.com
Dental caries is a costly and prevalent disease characterized by the demineralization of the
tooth's enamel. Disease outcome is influenced by host factors, dietary intake, cariogenic …

Strategies for Streptococcus mutans biofilm dispersal through extracellular polymeric substances disruption

Y Lin, X Zhou, Y Li - Molecular Oral Microbiology, 2022 - Wiley Online Library
Dental caries is one of the most prevalent and costly biofilm‐dependent oral infectious
diseases affecting most of the world's population. Streptococcus mutans, a major …

Antibacterial effects of natural compounds on biofilm formation of Streptococcus mutans

F Kamarehei, M Mehdiabadi… - Clinical and Experimental …, 2022 - Wiley Online Library
Streptococcus mutans is the main cariogenic pathogen in the oral cavity, considered to
contribute toward oral diseases. S. mutans is predominantly entrapped in plaque biofilms …

Inhibition of Streptococcus mutans biofilm formation by strategies targeting the metabolism of exopolysaccharides

Y Lin, J Chen, X Zhou, Y Li - Critical Reviews in Microbiology, 2021 - Taylor & Francis
Dental caries is one of the most prevalent and costly biofilm-associated infectious diseases
affecting most of the world's population. In particular, dental caries is driven by dysbiosis of …

Nanotechnology-based therapies for the prevention and treatment of Streptococcus mutans-derived dental caries

F Amissah, T Andey, KM Ahlschwede - Journal of oral biosciences, 2021 - Elsevier
Background Dental caries results from long-term acid production when sugar is metabolized
by a bacterial biofilm, resulting in a loss of calcium and phosphate from the enamel …

Regulatory mechanisms of exopolysaccharide synthesis and biofilm formation in Streptococcus mutans

T Zheng, M Jing, T Gong, J Yan, X Wang… - Journal of Oral …, 2023 - Taylor & Francis
Background Dental caries is a chronic, multifactorial and biofilm-mediated oral bacterial
infection affecting almost every age group and every geographical region. Streptococcus …

Targeted antimicrobial treatment to re-establish a healthy microbial flora for long-term protection

R Eckert, R Sullivan, W Shi - Advances in dental research, 2012 - journals.sagepub.com
Streptococcus mutans has been implicated as the major acid-producing (cariogenic)
bacterium. Dietary sugars and other factors may cause an imbalance of oral microflora that …

[HTML][HTML] Biofilm formation and virulence expression by Streptococcus mutans are altered when grown in dual-species model

ZT Wen, D Yates, SJ Ahn, RA Burne - BMC microbiology, 2010 - Springer
Background Microbial cell-cell interactions in the oral flora are believed to play an integral
role in the development of dental plaque and ultimately, its pathogenicity. The effects of …