For centuries, philosophers and scientists have been fascinated by the principles and
implications of regeneration in lower vertebrate species. Two features have made zebrafish …

Complex tissue regeneration involves exquisitely coordinated proliferation and patterning of
adult cells after severe injury or amputation. Certain lower vertebrates such as urodele …

Tissue damage can resolve completely through healing and regeneration, or can produce
permanent scarring and loss of function. The response to tissue damage varies across …

Adult fish, in contrast to mammals, are capable of regenerating axonal tracts as well as cells
and even entire tissues in the central nervous system (CNS). The zebrafish is a powerful …

The phenomenon of 'epimorphic regeneration', a complete reformation of lost tissues and
organs from adult differentiated cells, has been fascinating many biologists for many years …

Regeneration in the animal kingdom is one of the most fascinating problems that have
allowed scientists to address many issues of fundamental importance in basic biology …

Zebrafish have the remarkable ability to fully regenerate a lost appendage, faithfully
restoring its size, shape and tissue patterning. Studies over the past decades have identified …

Many organs regenerate well in adult zebrafish, but most research has been directed toward
fin and heart regeneration. Cells have been found to remain generally lineage-restricted …

The regenerative phenomenon is widespread, but regenerative capacity varies greatly
across animals. Invertebrates and phylogenetically primitive vertebrates, such as …

Heart disease remains a leading cause of mortality throughout the world. Mammals have an
extremely limited capacity to repair lost or damaged heart tissue, thus encouraging …