How hematopoietic stem cells (HSCs) coordinate their divisional axis relative to supportive
niche cells and whether or not their divisional orientation is important for stem cell-driven …

How hematopoietic stem cells (HSCs) coordinate their divisional axis and whether this
orientation is important for stem cell–driven hematopoiesis is poorly understood. Single-cell …

Shwachman–Diamond syndrome (SDS) is a bone marrow failure (BMF) syndrome
associated with an increased risk of myelodysplasia and leukemia. The molecular …

Hematopoietic stem cells are endowed with high regenerative potential but their actual self-
renewal capacity is limited. Studies using the H2B-retention labeling system show that HSC …

Haematopoietic stem cells (HSCs) reside in the bone marrow and are crucial for
replenishing blood cells throughout life. HSCs can differentiate into progenitors and …

Hematopoietic stem cells (HSCs) balance self-renewal and differentiation to maintain
homeostasis. With aging, the frequency of polar HSCs decreases. Cell polarity in HSCs is …

Effective manipulation of clinically relevant umbilical cord blood-derived human
hematopoietic stem cell (hHSC) fate decisions remains an important goal for improved …

Hematopoietic stem cells (HSCs) can self-renew and differentiate for the entire life of an
organism to produce new blood cells when needed. This process is regulated by …

Shwachman-Diamond syndrome (SDS) is an inherited multi-organ disorder with bone
marrow failure (BMF), which may include neutropenia, anemia, and thrombocytopenia, as …

Shwachman-Diamond syndrome (SDS) is an inherited bone marrow failure syndrome with
predisposition to developing leukemia. We found that multiple independent somatic …