Pannexins form channels at the plasma membrane surface that establish a pathway for
communication between the cytosol of individual cells and their extracellular environment …

Pannexins belong to a family of ATP-release channels expressed in almost all cell types. An
increasing body of literature on pannexins suggests that these channels play dual and …

Pannexins are large-pore ion channels with broad expression in the central nervous system
(CNS). The channels function by releasing large signaling molecules, such ATP and …

In less than a decade, a small family of channel-forming glycoproteins, named pannexins,
have captured the interest of many biologists, in large part due to their association with …

The pannexin family of channel-forming proteins is composed of 3 distinct but related
members called Panx1, Panx2, and Panx3. Pannexins have been implicated in many …

The Pannexin1 (Panx1) membrane channel responds to different stimuli with distinct
channel conformations. Most stimuli induce a large cation‐and ATP‐permeable …

Of the three pannexins in vertebrate proteomes, pannexin1 (Panx1) is the only one well
characterized, and it is generally accepted that Panx1 functions as an ATP release channel …

The large-pore channels formed by the pannexin family of proteins have been implicated in
many physiological and pathophysiological functions, mainly through their ATP release …

The Pannexin-1 (Panx1) channel is known to become activated under a variety of
physiological conditions resulting in the release of medium-sized molecules such as ATP …

Pannexins are a family of glycoproteins that comprises three members, PANX1, PANX2, and
PANX3. The widely expressed and interrogated PANX1 forms heptameric membrane …