In recent years, augmented renal clearance (ARC), in which renal function is excessively
enhanced, has been reported, and its influence on β-lactam antibiotics has been …

Purpose: Creatinine clearance (CCr) and pharmacokinetic parameters are markedly
affected by pathophysiological changes in patients with sepsis. However, only a few reports …

Purpose The aim of this study was to investigate the population pharmacokinetic (PK) profile
of meropenem in Korean patients with acute infections. Methods The study included 37 …

Introduction Meropenem is a carbapenem antibiotic, which has demonstrated excellent
antimicrobial activity against gram-negative clinical isolates. It is also commonly used in …

Effective antibiotic dosing is vital for therapeutic success in critically ill patients. This work
aimed to develop an algorithm to identify appropriate meropenem dosing in critically ill …

Several pathophysiological changes can alter meropenem pharmacokinetics in critically ill
patients, thereby increasing the risk of subtherapeutic concentrations and affecting …

Background and objective: Meropenem is a carbapenem antibacterial frequently prescribed
for the treatment of severe infections in critically ill patients, including those receiving …

Objectives The use of extended intermittent infusion (EII) or continuous infusion (CI) of
meropenem is recommended in intensive care unit (ICU) patients, but few data comparing …

What is known and Objective: Meropenem is frequently employed as an empirical treatment
for serious infections, but there has been no report on its population pharmacokinetic …

Pathophysiological changes during the early phase of severe sepsis and septic shock in
critically ill patients, resulting in altered pharmacokinetic (PK) patterns for antibiotics, are …