Left ventricular (LV) hypertrophy is an important physiological compensatory mechanism in
response to chronic increase in hemodynamic overload. There are two different forms of LV …

Background MicroRNAs (miRs) are a class of small non-coding RNAs that regulate gene
expression. Studies of transgenic mouse models have indicated that deregulation of a single …

MiRNAs regulate cardiac development, hypertrophy, and angiogenesis, but their role in
cardiac hypertrophy (CH) induced by aerobic training has not previously been studied …

Exercise training is beneficial to the cardiovascular system. MicroRNAs (miRNAs, miRs) are
a class of conserved non-coding RNAs and play a wide-ranging role in the regulation of …

Cardiovascular and metabolic diseases such as hypertension, type 2 diabetes, and obesity
develop long-term fibrotic processes in the heart, promoting pathological cardiac …

Cardiac hypertrophy is an adaptive enlargement of the myocardium in response to altered
stress or injury. The cellular responses of cardiomyocytes and non-cardiomyocytes to …

MicroRNAs (miRNAs) are a recently discovered class of∼ 22-nucleotide regulatory RNAs
that post-transcriptionally regulate gene expression. We have recently demonstrated that …

MicroRNAs (miRNAs) are small non-coding RNAs that control expression of complementary
target mRNAs. A growing number of miRNAs has been implicated in the pathogenesis of …

Purpose MicroRNA (miRNA)-126 is angiogenic and has two validated targets: Sprouty-
related protein 1 (Spred-1) and phosphoinositol-3 kinase regulatory subunit 2 (PI3KR2) …

MicroRNAs are naturally existing, small, noncoding RNA molecules that downregulate
posttranscriptional gene expression. Their expression pattern and function in the heart …