Using real-time TIRF microscopy imaging, we identify sites of clathrin and dynamin-
independent CLIC/GEEC (CG) endocytic vesicle formation. This allows spatio-temporal …

Small GTPases of the Arf family are best known for their role in vesicular transport, wherein
they nucleate the assembly of coat proteins at sites of carrier vesicle formation. However …

Vesicular trafficking and actin dynamics on Golgi membranes are both regulated by ADP-
ribosylation factor 1 (ARF1) through the recruitment of various effectors, including vesicular …

Clathrin-mediated endocytosis proceeds by a sequential series of reactions catalyzed by
discrete sets of protein machinery. The final reaction in clathrin-mediated endocytosis is …

Extracellular macromolecules, pathogens and cell surface proteins rely on endocytosis to
enter cells. Key steps of endocytic carrier formation are cargo molecule selection, plasma …

Endocytosis of glycosylphosphatidyl inositol (GPI)-anchored proteins (GPI-APs) and the fluid
phase takes place primarily through a dynamin-and clathrin-independent, Cdc42-regulated …

Several findings suggest that actin-mediated motility can play a role in clathrin-mediated
endocytosis but it remains unclear whether and when key proteins required for this process …

Motility requires protrusive activity at the cellular edge, where Rho family members regulate
actin dynamics. Here we show that p95-APP1 (ArfGAP-putative, Pix-interacting, paxillin …

Abstract The Arp2/3 complex, which is crucial for actin-based motility, nucleates actin
filaments and organizes them into y-branched networks. The Arp2 subunit has been shown …

The actin cytoskeleton has been implicated in protein trafficking at the Golgi apparatus and
in Golgi orientation and morphology. Actin dynamics at the Golgi are regulated in part by …