Patients with diabetes mellitus (DM) have a high prevalence of coronary artery disease
(CAD), as diabetes is implicated in the formation of atherosclerotic plaque. Endothelial …

Endothelial dysfunction is universal in diabetes, being intimately involved with the
development of cardiovascular disease. The pathogenesis of endothelial dysfunction in …

Abstract Type 2 diabetes (T2D) markedly increases the risk of cardiovascular disease.
Endothelial dysfunction (ED), an early indicator of diabetic vascular disease, is common in …

With the growing worldwide obesity epidemic, obesity, type 2 diabetes mellitus and
hypertension leading to premature cardiovascular events, are increasingly prevalent …

The main etiology for mortality and a great percentage of morbidity in patients with diabetes
mellitus is atherosclerosis. The pathogenesis of cardiovascular disease (CVD) in diabetes is …

Diabetes mellitus is associated with an increased risk of cardiovascular disease, even in the
presence of intensive glycemic control. Substantial clinical and experimental evidence …

Micro-and macrovascular complications are major causes of disability and death in patients
with diabetes mellitus. Functional impairment of endothelial activity precedes the …

The vascular endothelium is a multifunctional organ and is critically involved in modulating
vascular tone and structure. Endothelial cells produce a wide range of factors that also …

Endothelial dysfunction is an imbalance in the production of vasodilator factors and when
this balance is disrupted, it predisposes the vasculature towards pro-thrombotic and pro …

It is widely accepted that diabetes mellitus (DM) impairs endothelial nitric oxide synthase
activity as well as enhances the production of reactive oxygen species, thus resulting in …